Names & Taxonomy
- Uniprot ID:
- P16109
- Entry Name:
- LYAM3_HUMAN
- Status:
- reviewed
- Protein Names:
- P-selectin (CD62 antigen-like family member P) (Granule membrane protein 140) (GMP-140) (Leukocyte-endothelial cell adhesion molecule 3) (LECAM3) (Platelet activation dependent granule-external membrane protein) (PADGEM) (CD antigen CD62P)
- Gene Names:
- SELP GMRP GRMP
- Gene Names Primary:
- SELP
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 830
- Sequence:
- MANCQIAILYQRFQRVVFGISQLLCFSALISELTNQKEVAAWTYHYSTKAYSWNISRKYCQNRYTDLVAIQNKNEIDYLNKVLPYYSSYYWIGIRKNNKTWTWVGTKKALTNEAENWADNEPNNKRNNEDCVEIYIKSPSAPGKWNDEHCLKKKHALCYTASCQDMSCSKQGECLETIGNYTCSCYPGFYGPECEYVRECGELELPQHVLMNCSHPLGNFSFNSQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQCLAAQCPPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPECQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSATPPTCKGIASLPTPGLQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRPSGQWTAVTPACRAVKCSELHVNKPIAMNCSNLWGNFSYGSICSFHCLEGQLLNGSAQTACQENGHWSTTVPTCQAGPLTIQEALTYFGGAVASTIGLIMGGTLLALLRKRFRQKDDGKCPLNPHSHLGTYGVFTNAAFDPSP
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Single-pass type I membrane protein.
Function
- Function:
- Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1.
- Cross Reference Drug Bank:
- DB06779 DB01109 DB08813
- Gene Ontology Go:
- cytoplasm
external side of plasma membrane
extracellular space
integral component of plasma membrane
nucleoplasm
plasma membrane
platelet alpha granule membrane
platelet dense granule membrane
fucose binding
glycosphingolipid binding
heparin binding
lipopolysaccharide binding
oligosaccharide binding
sialic acid binding
blood coagulation
calcium-mediated signaling using intracellular calcium source
cell adhesion
defense response to Gram-negative bacterium
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
inflammatory response
leukocyte cell-cell adhesion
leukocyte migration
leukocyte tethering or rolling
platelet activation
platelet degranulation
positive regulation of cell adhesion
positive regulation of leukocyte migration
positive regulation of phosphatidylinositol 3-kinase signaling
positive regulation of platelet activation
regulation of cellular extravasation
regulation of integrin activation
response to lipopolysaccharide
response to organic cyclic compound - Gene Ontology Biological Process:
- blood coagulation
calcium-mediated signaling using intracellular calcium source
cell adhesion
defense response to Gram-negative bacterium
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
inflammatory response
leukocyte cell-cell adhesion
leukocyte migration
leukocyte tethering or rolling
platelet activation
platelet degranulation
positive regulation of cell adhesion
positive regulation of leukocyte migration
positive regulation of phosphatidylinositol 3-kinase signaling
positive regulation of platelet activation
regulation of cellular extravasation
regulation of integrin activation
response to lipopolysaccharide
response to organic cyclic compound - Gene Ontology Molecular Function:
- fucose binding
glycosphingolipid binding
heparin binding
lipopolysaccharide binding
oligosaccharide binding
sialic acid binding - Gene Ontology Cellular Component:
- cytoplasm
external side of plasma membrane
extracellular space
integral component of plasma membrane
nucleoplasm
plasma membrane
platelet alpha granule membrane
platelet dense granule membrane - Keywords:
- 3D-structure
Cell adhesion
Complete proteome
Disulfide bond
EGF-like domain
Glycoprotein
Lectin
Lipoprotein
Membrane
Palmitate
Polymorphism
Reference proteome
Repeat
Signal
Sushi
Transmembrane
Transmembrane helix - Interacts With:
- Q14242