Names & Taxonomy
- Uniprot ID:
- P16070
- Entry Name:
- CD44_HUMAN
- Status:
- reviewed
- Protein Names:
- CD44 antigen (CDw44) (Epican) (Extracellular matrix receptor III) (ECMR-III) (GP90 lymphocyte homing/adhesion receptor) (HUTCH-I) (Heparan sulfate proteoglycan) (Hermes antigen) (Hyaluronate receptor) (Phagocytic glycoprotein 1) (PGP-1) (Phagocytic glycoprotein I) (PGP-I) (CD antigen CD44)
- Gene Names:
- CD44 LHR MDU2 MDU3 MIC4
- Gene Names Primary:
- CD44
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 742
- Sequence:
- MDKFWWHAAWGLCLVPLSLAQIDLNITCRFAGVFHVEKNGRYSISRTEAADLCKAFNSTLPTMAQMEKALSIGFETCRYGFIEGHVVIPRIHPNSICAANNTGVYILTSNTSQYDTYCFNASAPPEEDCTSVTDLPNAFDGPITITIVNRDGTRYVQKGEYRTNPEDIYPSNPTDDDVSSGSSSERSSTSGGYIFYTFSTVHPIPDEDSPWITDSTDRIPATTLMSTSATATETATKRQETWDWFSWLFLPSESKNHLHTTTQMAGTSSNTISAGWEPNEENEDERDRHLSFSGSGIDDDEDFISSTISTTPRAFDHTKQNQDWTQWNPSHSNPEVLLQTTTRMTDVDRNGTTAYEGNWNPEAHPPLIHHEHHEEEETPHSTSTIQATPSSTTEETATQKEQWFGNRWHEGYRQTPKEDSHSTTGTAAASAHTSHPMQGRTTPSPEDSSWTDFFNPISHPMGRGHQAGRRMDMDSSHSITLQPTANPNTGLVEDLDRTGPLSMTTQQSNSQSFSTSHEGLEEDKDHPTTSTLTSSNRNDVTGGRRDPNHSEGSTTLLEGYTSHYPHTKESRTFIPVTSAKTGSFGVTAVTVGDSNSNVNRSLSGDQDTFHPSGGSHTTHGSESDGHSHGSQEGGANTTSGPIRTPQIPEWLIILASLLALALILAVCIAVNSRRRCGQKKKLVINSGNGAVEDRKPSGLNGEASKSQEMVHLVNKESSETPDQFMTADETRNLQNVDMKIGV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. Receptor for LGALS9; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function (By similarity).
- Cross Reference Drug Bank:
- DB08818
- Gene Ontology Go:
- cell surface
cytoplasm
extracellular exosome
focal adhesion
Golgi apparatus
integral component of plasma membrane
macrophage migration inhibitory factor receptor complex
plasma membrane
collagen binding
hyaluronic acid binding
hyalurononglucosaminidase activity
blood coagulation
carbohydrate metabolic process
cartilage development
cell-matrix adhesion
cellular response to fibroblast growth factor stimulus
cytokine-mediated signaling pathway
extracellular matrix disassembly
extracellular matrix organization
glycosaminoglycan metabolic process
hyaluronan catabolic process
hyaluronan metabolic process
interferon-gamma-mediated signaling pathway
leukocyte migration
monocyte aggregation
negative regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of DNA damage response, signal transduction by p53 class mediator
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
positive regulation of ERK1 and ERK2 cascade
positive regulation of heterotypic cell-cell adhesion
positive regulation of monocyte aggregation
positive regulation of peptidyl-serine phosphorylation
positive regulation of peptidyl-tyrosine phosphorylation
single organismal cell-cell adhesion
small molecule metabolic process - Gene Ontology Biological Process:
- blood coagulation
carbohydrate metabolic process
cartilage development
cell-matrix adhesion
cellular response to fibroblast growth factor stimulus
cytokine-mediated signaling pathway
extracellular matrix disassembly
extracellular matrix organization
glycosaminoglycan metabolic process
hyaluronan catabolic process
hyaluronan metabolic process
interferon-gamma-mediated signaling pathway
leukocyte migration
monocyte aggregation
negative regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of DNA damage response, signal transduction by p53 class mediator
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
positive regulation of ERK1 and ERK2 cascade
positive regulation of heterotypic cell-cell adhesion
positive regulation of monocyte aggregation
positive regulation of peptidyl-serine phosphorylation
positive regulation of peptidyl-tyrosine phosphorylation
single organismal cell-cell adhesion
small molecule metabolic process - Gene Ontology Molecular Function:
- collagen binding
hyaluronic acid binding
hyalurononglucosaminidase activity - Gene Ontology Cellular Component:
- cell surface
cytoplasm
extracellular exosome
focal adhesion
Golgi apparatus
integral component of plasma membrane
macrophage migration inhibitory factor receptor complex
plasma membrane - Keywords:
- 3D-structure
Alternative splicing
Blood group antigen
Cell adhesion
Cell membrane
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
Membrane
Phosphoprotein
Polymorphism
Proteoglycan
Pyrrolidone carboxylic acid
Receptor
Reference proteome
Signal
Transmembrane
Transmembrane helix - Interacts With:
- P18011; P26038; Q9UPY5; P10451
Publication
- PubMed ID:
- 2466575 1840487 1991450 2056274 1281868 1465456 7508842 8352881 10933060 17974005 16554811 15489334 1922057 2466576 7527301 7508992 2007624 8148709 1717145 12511867 9580567 12032545 12883358 16335952 17081983 16541107 19367720 18691976 18669648 19159218 19381274 19690332 20068231 21269460 22171320 21406692 24275569 25944712 14992719 17085435 8636151