Names & Taxonomy
- Uniprot ID:
- P15559
- Entry Name:
- NQO1_HUMAN
- Status:
- reviewed
- Protein Names:
- NAD(P)H dehydrogenase [quinone] 1 (EC 1.6.5.2) (Azoreductase) (DT-diaphorase) (DTD) (Menadione reductase) (NAD(P)H:quinone oxidoreductase 1) (Phylloquinone reductase) (Quinone reductase 1) (QR1)
- Gene Names:
- NQO1 DIA4 NMOR1
- Gene Names Primary:
- NQO1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 274
- Sequence:
- MVGRRALIVLAHSERTSFNYAMKEAAAAALKKKGWEVVESDLYAMNFNPIISRKDITGKLKDPANFQYPAESVLAYKEGHLSPDIVAEQKKLEAADLVIFQFPLQWFGVPAILKGWFERVFIGEFAYTYAAMYDKGPFRSKKAVLSITTGGSGSMYSLQGIHGDMNVILWPIQSGILHFCGFQVLEPQLTYSIGHTPADARIQILEGWKKRLENIWDETPLYFAPSSLFDLNFQAGFLMKKEVQDEEKNKKFGLSVGHHLGKSIPTDNQIKARK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Function:
- The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.
- Catalytic Activity:
- NAD(P)H + a quinone = NAD(P)(+) + a hydroquinone.
- Cofactor:
- COFACTOR: Name=FAD; Xref=ChEBI:CHEBI:57692;
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited by dicoumarol.
- Cross Reference Drug Bank:
- DB00958 DB00515 DB00266 DB00997 DB03147 DB00170 DB00526 DB00163
- Gene Ontology Go:
- cytoplasm
cytosol
extracellular exosome
neuronal cell body
cytochrome-b5 reductase activity, acting on NAD(P)H
identical protein binding
NAD(P)H dehydrogenase (quinone) activity
poly(A) RNA binding
superoxide dismutase activity
aging
cellular nitrogen compound metabolic process
negative regulation of catalytic activity
nitric oxide biosynthetic process
polyamine metabolic process
positive regulation of neuron apoptotic process
regulation of cellular amino acid metabolic process
response to estradiol
response to ethanol
response to nutrient
response to toxic substance
small molecule metabolic process
synaptic transmission, cholinergic
xenobiotic metabolic process - Gene Ontology Biological Process:
- aging
cellular nitrogen compound metabolic process
negative regulation of catalytic activity
nitric oxide biosynthetic process
polyamine metabolic process
positive regulation of neuron apoptotic process
regulation of cellular amino acid metabolic process
response to estradiol
response to ethanol
response to nutrient
response to toxic substance
small molecule metabolic process
synaptic transmission, cholinergic
xenobiotic metabolic process - Gene Ontology Molecular Function:
- cytochrome-b5 reductase activity, acting on NAD(P)H
identical protein binding
NAD(P)H dehydrogenase (quinone) activity
poly(A) RNA binding
superoxide dismutase activity - Gene Ontology Cellular Component:
- cytoplasm
cytosol
extracellular exosome
neuronal cell body - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Cytoplasm
FAD
Flavoprotein
NAD
NADP
Oxidoreductase
Polymorphism
Reference proteome - Interacts With:
- Itself; Q9UK53; O88898-2; O88898-6