Names & Taxonomy
- Uniprot ID:
- P15502
- Entry Name:
- ELN_HUMAN
- Status:
- reviewed
- Protein Names:
- Elastin (Tropoelastin)
- Gene Names:
- ELN
- Gene Names Primary:
- ELN
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 786
- Sequence:
- MAGLTAAAPRPGVLLLLLSILHPSRPGGVPGAIPGGVPGGVFYPGAGLGALGGGALGPGGKPLKPVPGGLAGAGLGAGLGAFPAVTFPGALVPGGVADAAAAYKAAKAGAGLGGVPGVGGLGVSAGAVVPQPGAGVKPGKVPGVGLPGVYPGGVLPGARFPGVGVLPGVPTGAGVKPKAPGVGGAFAGIPGVGPFGGPQPGVPLGYPIKAPKLPGGYGLPYTTGKLPYGYGPGGVAGAAGKAGYPTGTGVGPQAAAAAAAKAAAKFGAGAAGVLPGVGGAGVPGVPGAIPGIGGIAGVGTPAAAAAAAAAAKAAKYGAAAGLVPGGPGFGPGVVGVPGAGVPGVGVPGAGIPVVPGAGIPGAAVPGVVSPEAAAKAAAKAAKYGARPGVGVGGIPTYGVGAGGFPGFGVGVGGIPGVAGVPGVGGVPGVGGVPGVGISPEAQAAAAAKAAKYGAAGAGVLGGLVPGPQAAVPGVPGTGGVPGVGTPAAAAAKAAAKAAQFGLVPGVGVAPGVGVAPGVGVAPGVGLAPGVGVAPGVGVAPGVGVAPGIGPGGVAAAAKSAAKVAAKAQLRAAAGLGAGIPGLGVGVGVPGLGVGAGVPGLGVGAGVPGFGAGADEGVRRSLSPELREGDPSSSQHLPSTPSSPRVPGALAAAKAAKYGAAVPGVLGGLGALGGVGIPGGVVGAGPAAAAAAAKAAAKAAQFGLVGAAGLGGLGVGGLGVPGVGGLGGIPPAAAAKAAKYGAAGLGGVLGGAGQFPLGGVAARPGFGLSPIFPGGACLGKACGRKRK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted, extracellular space, extracellular matrix
Function
- Function:
- Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle (By similarity).
- Gene Ontology Go:
- elastic fiber
extracellular region
proteinaceous extracellular matrix
extracellular matrix structural constituent
blood circulation
cell proliferation
extracellular matrix disassembly
extracellular matrix organization
organ morphogenesis
respiratory gaseous exchange - Gene Ontology Biological Process:
- blood circulation
cell proliferation
extracellular matrix disassembly
extracellular matrix organization
organ morphogenesis
respiratory gaseous exchange - Gene Ontology Molecular Function:
- extracellular matrix structural constituent
- Gene Ontology Cellular Component:
- elastic fiber
extracellular region
proteinaceous extracellular matrix - Keywords:
- Alternative splicing
Complete proteome
Disulfide bond
Extracellular matrix
Hydroxylation
Polymorphism
Reference proteome
Repeat
Secreted
Signal
Williams-Beuren syndrome - Interacts With:
- O95967; Q9UBX5; P28300