Names & Taxonomy

Uniprot ID:
P15260
Entry Name:
INGR1_HUMAN
Status:
reviewed
Protein Names:
Interferon gamma receptor 1 (IFN-gamma receptor 1) (IFN-gamma-R1) (CDw119) (CD antigen CD119)
Gene Names:
IFNGR1
Gene Names Primary:
IFNGR1
Organism:
Homo sapiens (Human)

Structure

Length:
489
Sequence:
MALLFLLPLVMQGVSRAEMGTADLGPSSVPTPTNVTIESYNMNPIVYWEYQIMPQVPVFTVEVKNYGVKNSEWIDACINISHHYCNISDHVGDPSNSLWVRVKARVGQKESAYAKSEEFAVCRDGKIGPPKLDIRKEEKQIMIDIFHPSVFVNGDEQEVDYDPETTCYIRVYNVYVRMNGSEIQYKILTQKEDDCDEIQCQLAIPVSSLNSQYCVSAEGVLHVWGVTTEKSKEVCITIFNSSIKGSLWIPVVAALLLFLVLSLVFICFYIKKINPLKEKSIILPKSLISVVRSATLETKPESKYVSLITSYQPFSLEKEVVCEEPLSPATVPGMHTEDNPGKVEHTEELSSITEVVTTEENIPDVVPGSHLTPIERESSSPLSSNQSEPGSIALNSYHSRNCSESDHSRNGFDTDSSCLESHSSLSDSEFPPNNKGEIKTEGQELITVIKAPTSFGYDKPHVLVDLLVDDSGKESLIGYRPTEDSKEFS
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane

Function

Function:
Associates with IFNGR2 to form a receptor for the cytokine interferon gamma (IFNG) (PubMed:7615558, PubMed:2971451, PubMed:7617032, PubMed:10986460). Ligand binding stimulates activation of the JAK/STAT signaling pathway (PubMed:7673114).
Cross Reference Drug Bank:
DB00033
Gene Ontology Go:
integral component of plasma membrane
plasma membrane
interferon-gamma receptor activity
interleukin-20 binding
cytokine-mediated signaling pathway
interferon-gamma-mediated signaling pathway
regulation of interferon-gamma-mediated signaling pathway
response to virus
signal transduction
Gene Ontology Biological Process:
cytokine-mediated signaling pathway
interferon-gamma-mediated signaling pathway
regulation of interferon-gamma-mediated signaling pathway
response to virus
signal transduction
Gene Ontology Molecular Function:
interferon-gamma receptor activity
interleukin-20 binding
Gene Ontology Cellular Component:
integral component of plasma membrane
plasma membrane
Keywords:
3D-structure
Alternative splicing
Cell membrane
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
Glycoprotein
Immunoglobulin domain
Membrane
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Signal
Transmembrane
Transmembrane helix
Interacts With:
P42224

Publication

PubMed ID:
2971451 14702039 14574404 15489334 8443182 7615558 7673114 10192386 7617032 9367779 10986460 9389728 10811850 12516030