Names & Taxonomy
- Uniprot ID:
- P15144
- Entry Name:
- AMPN_HUMAN
- Status:
- reviewed
- Protein Names:
- Aminopeptidase N (AP-N) (hAPN) (EC 3.4.11.2) (Alanyl aminopeptidase) (Aminopeptidase M) (AP-M) (Microsomal aminopeptidase) (Myeloid plasma membrane glycoprotein CD13) (gp150) (CD antigen CD13)
- Gene Names:
- ANPEP APN CD13 PEPN
- Gene Names Primary:
- ANPEP
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 967
- Sequence:
- MAKGFYISKSLGILGILLGVAAVCTIIALSVVYSQEKNKNANSSPVASTTPSASATTNPASATTLDQSKAWNRYRLPNTLKPDSYRVTLRPYLTPNDRGLYVFKGSSTVRFTCKEATDVIIIHSKKLNYTLSQGHRVVLRGVGGSQPPDIDKTELVEPTEYLVVHLKGSLVKDSQYEMDSEFEGELADDLAGFYRSEYMEGNVRKVVATTQMQAADARKSFPCFDEPAMKAEFNITLIHPKDLTALSNMLPKGPSTPLPEDPNWNVTEFHTTPKMSTYLLAFIVSEFDYVEKQASNGVLIRIWARPSAIAAGHGDYALNVTGPILNFFAGHYDTPYPLPKSDQIGLPDFNAGAMENWGLVTYRENSLLFDPLSSSSSNKERVVTVIAHELAHQWFGNLVTIEWWNDLWLNEGFASYVEYLGADYAEPTWNLKDLMVLNDVYRVMAVDALASSHPLSTPASEINTPAQISELFDAISYSKGASVLRMLSSFLSEDVFKQGLASYLHTFAYQNTIYLNLWDHLQEAVNNRSIQLPTTVRDIMNRWTLQMGFPVITVDTSTGTLSQEHFLLDPDSNVTRPSEFNYVWIVPITSIRDGRQQQDYWLIDVRAQNDLFSTSGNEWVLLNLNVTGYYRVNYDEENWRKIQTQLQRDHSAIPVINRAQIINDAFNLASAHKVPVTLALNNTLFLIEERQYMPWEAALSSLSYFKLMFDRSEVYGPMKNYLKKQVTPLFIHFRNNTNNWREIPENLMDQYSEVNAISTACSNGVPECEEMVSGLFKQWMENPNNNPIHPNLRSTVYCNAIAQGGEEEWDFAWEQFRNATLVNEADKLRAALACSKELWILNRYLSYTLNPDLIRKQDATSTIISITNNVIGQGLVWDFVQSNWKKLFNDYGGGSFSFSNLIQAVTRRFSTEYELQQLEQFKKDNEETGFGSGTRALEQALEKTKANIKWVKENKEVVLQWFTENSK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Single-pass type II membrane protein. Cytoplasm, cytosol
Function
- Function:
- Broad specificity aminopeptidase. Plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. May play a critical role in the pathogenesis of cholesterol gallstone disease. May be involved in the metabolism of regulatory peptides of diverse cell types, responsible for the processing of peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. Found to cleave antigen peptides bound to major histocompatibility complex class II molecules of presenting cells and to degrade neurotransmitters at synaptic junctions. Is also implicated as a regulator of IL-8 bioavailability in the endometrium, and therefore may contribute to the regulation of angiogenesis. Is used as a marker for acute myeloid leukemia and plays a role in tumor invasion. In case of human coronavirus 229E (HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein. Mediates as well human cytomegalovirus (HCMV) infection.
- Catalytic Activity:
- Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.
- Cofactor:
- COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Active Site:
- ACT_SITE 389 389 Proton acceptor.
- Cross Reference Drug Bank:
- DB00973 DB06196
- Gene Ontology Go:
- cytosol
endoplasmic reticulum-Golgi intermediate compartment
external side of plasma membrane
extracellular exosome
extracellular space
integral component of plasma membrane
lysosomal membrane
vesicle lumen
vesicle membrane
aminopeptidase activity
metalloaminopeptidase activity
metallopeptidase activity
peptide binding
receptor activity
virus receptor activity
zinc ion binding
angiogenesis
angiotensin maturation
cell differentiation
cellular aromatic compound metabolic process
cellular protein metabolic process
negative regulation of renal sodium excretion
peptide catabolic process - Gene Ontology Biological Process:
- angiogenesis
angiotensin maturation
cell differentiation
cellular aromatic compound metabolic process
cellular protein metabolic process
negative regulation of renal sodium excretion
peptide catabolic process - Gene Ontology Molecular Function:
- aminopeptidase activity
metalloaminopeptidase activity
metallopeptidase activity
peptide binding
receptor activity
virus receptor activity
zinc ion binding - Gene Ontology Cellular Component:
- cytosol
endoplasmic reticulum-Golgi intermediate compartment
external side of plasma membrane
extracellular exosome
extracellular space
integral component of plasma membrane
lysosomal membrane
vesicle lumen
vesicle membrane - Keywords:
- 3D-structure
Aminopeptidase
Angiogenesis
Cell membrane
Complete proteome
Cytoplasm
Developmental protein
Differentiation
Direct protein sequencing
Disulfide bond
Glycoprotein
Host cell receptor for virus entry
Host-virus interaction
Hydrolase
Membrane
Metal-binding
Metalloprotease
Polymorphism
Protease
Receptor
Reference proteome
Signal-anchor
Sulfation
Transmembrane
Transmembrane helix
Zinc