Names & Taxonomy
- Uniprot ID:
- P15085
- Entry Name:
- CBPA1_HUMAN
- Status:
- reviewed
- Protein Names:
- Carboxypeptidase A1 (EC 3.4.17.1)
- Gene Names:
- CPA1 CPA
- Gene Names Primary:
- CPA1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 419
- Sequence:
- MRGLLVLSVLLGAVFGKEDFVGHQVLRISVADEAQVQKVKELEDLEHLQLDFWRGPAHPGSPIDVRVPFPSIQAVKIFLESHGISYETMIEDVQSLLDEEQEQMFAFRSRARSTDTFNYATYHTLEEIYDFLDLLVAENPHLVSKIQIGNTYEGRPIYVLKFSTGGSKRPAIWIDTGIHSREWVTQASGVWFAKKITQDYGQDAAFTAILDTLDIFLEIVTNPDGFAFTHSTNRMWRKTRSHTAGSLCIGVDPNRNWDAGFGLSGASSNPCSETYHGKFANSEVEVKSIVDFVKDHGNIKAFISIHSYSQLLMYPYGYKTEPVPDQDELDQLSKAAVTALASLYGTKFNYGSIIKAIYQASGSTIDWTYSQGIKYSFTFELRDTGRYGFLLPASQIIPTAKETWLALLTIMEHTLNHPY
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted.
Function
- Function:
- Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.
- Catalytic Activity:
- Release of a C-terminal amino acid, but little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.
- Cofactor:
- COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Active Site:
- ACT_SITE 380 380 Proton donor/acceptor.
- Gene Ontology Go:
- extracellular space
metallocarboxypeptidase activity
zinc ion binding
proteolysis - Gene Ontology Biological Process:
- proteolysis
- Gene Ontology Molecular Function:
- metallocarboxypeptidase activity
zinc ion binding - Gene Ontology Cellular Component:
- extracellular space
- Keywords:
- 3D-structure
Carboxypeptidase
Complete proteome
Direct protein sequencing
Disulfide bond
Hydrolase
Metal-binding
Metalloprotease
Polymorphism
Protease
Reference proteome
Secreted
Signal
Zinc
Zymogen