Names & Taxonomy
- Uniprot ID:
- P14920
- Entry Name:
- OXDA_HUMAN
- Status:
- reviewed
- Protein Names:
- D-amino-acid oxidase (DAAO) (DAMOX) (DAO) (EC 1.4.3.3)
- Gene Names:
- DAO DAMOX
- Gene Names Primary:
- DAO
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 347
- Sequence:
- MRVVVIGAGVIGLSTALCIHERYHSVLQPLDIKVYADRFTPLTTTDVAAGLWQPYLSDPNNPQEADWSQQTFDYLLSHVHSPNAENLGLFLISGYNLFHEAIPDPSWKDTVLGFRKLTPRELDMFPDYGYGWFHTSLILEGKNYLQWLTERLTERGVKFFQRKVESFEEVAREGADVIVNCTGVWAGALQRDPLLQPGRGQIMKVDAPWMKHFILTHDPERGIYNSPYIIPGTQTVTLGGIFQLGNWSELNNIQDHNTIWEGCCRLEPTLKNARIIGERTGFRPVRPQIRLEREQLRTGPSNTEVIHNYGHGGYGLTIHWGCALEAAKLFGRILEEKKLSRMPPSHL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Peroxisome.
Function
- Function:
- Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.
- Catalytic Activity:
- A D-amino acid + H(2)O + O(2) = a 2-oxo acid + NH(3) + H(2)O(2).
- Cofactor:
- COFACTOR: Name=FAD; Xref=ChEBI:CHEBI:57692;
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=3.6 mM for D-serine
- Cross Reference Drug Bank:
- DB03793 DB03147
- Gene Ontology Go:
- cytosol
peroxisomal matrix
peroxisomal membrane
peroxisome
cofactor binding
D-amino-acid oxidase activity
FAD binding
protein dimerization activity
receptor binding
cellular nitrogen compound metabolic process
D-alanine catabolic process
D-serine catabolic process
D-serine metabolic process
dopamine biosynthetic process
glyoxylate metabolic process
proline catabolic process
small molecule metabolic process - Gene Ontology Biological Process:
- cellular nitrogen compound metabolic process
D-alanine catabolic process
dopamine biosynthetic process
D-serine catabolic process
D-serine metabolic process
glyoxylate metabolic process
proline catabolic process
small molecule metabolic process - Gene Ontology Molecular Function:
- cofactor binding
D-amino-acid oxidase activity
FAD binding
protein dimerization activity
receptor binding - Gene Ontology Cellular Component:
- cytosol
peroxisomal matrix
peroxisomal membrane
peroxisome - Keywords:
- 3D-structure
Complete proteome
FAD
Flavoprotein
Oxidoreductase
Peroxisome
Reference proteome - Interacts With:
- O43741