Names & Taxonomy
- Uniprot ID:
- P14770
- Entry Name:
- GPIX_HUMAN
- Status:
- reviewed
- Protein Names:
- Platelet glycoprotein IX (GP-IX) (GPIX) (Glycoprotein 9) (CD antigen CD42a)
- Gene Names:
- GP9
- Gene Names Primary:
- GP9
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 177
- Sequence:
- MPAWGALFLLWATAEATKDCPSPCTCRALETMGLWVDCRGHGLTALPALPARTRHLLLANNSLQSVPPGAFDHLPQLQTLDVTQNPWHCDCSLTYLRLWLEDRTPEALLQVRCASPSLAAHGPLGRLTGYQLGSCGWQLQASWVRPGVLWDVALVAVAALGLALLAGLLCATTEALD
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Single-pass type I membrane protein.
Function
- Function:
- The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis. GP-IX may provide for membrane insertion and orientation of GP-Ib.
- Cross Reference Drug Bank:
- DB00468
- Gene Ontology Go:
- integral component of plasma membrane
plasma membrane
blood coagulation
blood coagulation, intrinsic pathway
cell adhesion
platelet activation - Gene Ontology Biological Process:
- blood coagulation
blood coagulation, intrinsic pathway
cell adhesion
platelet activation - Gene Ontology Cellular Component:
- integral component of plasma membrane
plasma membrane - Keywords:
- 3D-structure
Bernard Soulier syndrome
Blood coagulation
Cell adhesion
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
Glycoprotein
Hemostasis
Leucine-rich repeat
Membrane
Reference proteome
Signal
Transmembrane
Transmembrane helix - Interacts With:
- P40197; P49639; O43597