Names & Taxonomy
- Uniprot ID:
- P14625
- Entry Name:
- ENPL_HUMAN
- Status:
- reviewed
- Protein Names:
- Endoplasmin (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) (Tumor rejection antigen 1) (gp96 homolog)
- Gene Names:
- HSP90B1 GRP94 TRA1
- Gene Names Primary:
- HSP90B1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 803
- Sequence:
- MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum lumen. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Function
- Function:
- Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity.
- Cross Reference Drug Bank:
- DB00615
- Gene Ontology Go:
- cytosol
endocytic vesicle lumen
endoplasmic reticulum
endoplasmic reticulum chaperone complex
endoplasmic reticulum lumen
endoplasmic reticulum membrane
extracellular exosome
extracellular matrix
extracellular region
focal adhesion
melanosome
membrane
midbody
nucleus
perinuclear region of cytoplasm
plasma membrane
ATP binding
calcium ion binding
low-density lipoprotein particle receptor binding
protein phosphatase binding
RNA binding
virion binding
actin rod assembly
ATF6-mediated unfolded protein response
cellular protein metabolic process
cellular response to ATP
endoplasmic reticulum unfolded protein response
ER-associated ubiquitin-dependent protein catabolic process
innate immune response
negative regulation of apoptotic process
protein folding in endoplasmic reticulum
protein transport
receptor-mediated endocytosis
regulation of phosphoprotein phosphatase activity
response to endoplasmic reticulum stress
response to hypoxia
retrograde protein transport, ER to cytosol
sequestering of calcium ion
toll-like receptor signaling pathway - Gene Ontology Biological Process:
- actin rod assembly
ATF6-mediated unfolded protein response
cellular protein metabolic process
cellular response to ATP
endoplasmic reticulum unfolded protein response
ER-associated ubiquitin-dependent protein catabolic process
innate immune response
negative regulation of apoptotic process
protein folding in endoplasmic reticulum
protein transport
receptor-mediated endocytosis
regulation of phosphoprotein phosphatase activity
response to endoplasmic reticulum stress
response to hypoxia
retrograde protein transport, ER to cytosol
sequestering of calcium ion
toll-like receptor signaling pathway - Gene Ontology Molecular Function:
- ATP binding
calcium ion binding
low-density lipoprotein particle receptor binding
protein phosphatase binding
RNA binding
virion binding - Gene Ontology Cellular Component:
- cytosol
endocytic vesicle lumen
endoplasmic reticulum
endoplasmic reticulum chaperone complex
endoplasmic reticulum lumen
endoplasmic reticulum membrane
extracellular exosome
extracellular matrix
extracellular region
focal adhesion
melanosome
membrane
midbody
nucleus
perinuclear region of cytoplasm
plasma membrane - Keywords:
- 3D-structure
ATP-binding
Acetylation
Calcium
Chaperone
Complete proteome
Direct protein sequencing
Disulfide bond
Endoplasmic reticulum
Glycoprotein
Nucleotide-binding
Phosphoprotein
Reference proteome
Signal - Interacts With:
- Q00597