Names & Taxonomy
- Uniprot ID:
- P14598
- Entry Name:
- NCF1_HUMAN
- Status:
- reviewed
- Protein Names:
- Neutrophil cytosol factor 1 (NCF-1) (47 kDa autosomal chronic granulomatous disease protein) (47 kDa neutrophil oxidase factor) (NCF-47K) (Neutrophil NADPH oxidase factor 1) (Nox organizer 2) (Nox-organizing protein 2) (SH3 and PX domain-containing protein 1A) (p47-phox)
- Gene Names:
- NCF1 NOXO2 SH3PXD1A
- Gene Names Primary:
- NCF1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 390
- Sequence:
- MGDTFIRHIALLGFEKRFVPSQHYVYMFLVKWQDLSEKVVYRRFTEIYEFHKTLKEMFPIEAGAINPENRIIPHLPAPKWFDGQRAAENRQGTLTEYCGTLMSLPTKISRCPHLLDFFKVRPDDLKLPTDNQTKKPETYLMPKDGKSTATDITGPIILQTYRAIANYEKTSGSEMALSTGDVVEVVEKSESGWWFCQMKAKRGWIPASFLEPLDSPDETEDPEPNYAGEPYVAIKAYTAVEGDEVSLLEGEAVEVIHKLLDGWWVIRKDDVTGYFPSMYLQKSGQDVSQAQRQIKRGAPPRRSSIRNAHSIHQRSRKRLSQDAYRRNSVRFLQQRRRQARPGPQSPGSPLEEERQTQRSKPQPAVPPRPSADLILNRCSESTKRKLASAV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm, cytosol
Function
- Function:
- NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).
- Cross Reference Drug Bank:
- DB00514
- Gene Ontology Go:
- cytosol
extrinsic component of membrane
NADPH oxidase complex
phagolysosome
electron carrier activity
phosphatidylinositol binding
phosphatidylinositol-3,4-bisphosphate binding
SH3 domain binding
superoxide-generating NADPH oxidase activity
antigen processing and presentation of exogenous peptide antigen via MHC class I
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
antigen processing and presentation of peptide antigen via MHC class I
cell redox homeostasis
cellular defense response
innate immune response
oxidation-reduction process
protein targeting to membrane
respiratory burst
small GTPase mediated signal transduction
superoxide anion generation
superoxide metabolic process
vascular endothelial growth factor receptor signaling pathway - Gene Ontology Biological Process:
- antigen processing and presentation of exogenous peptide antigen via MHC class I
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
antigen processing and presentation of peptide antigen via MHC class I
cell redox homeostasis
cellular defense response
innate immune response
oxidation-reduction process
protein targeting to membrane
respiratory burst
small GTPase mediated signal transduction
superoxide anion generation
superoxide metabolic process
vascular endothelial growth factor receptor signaling pathway - Gene Ontology Molecular Function:
- electron carrier activity
phosphatidylinositol-3,4-bisphosphate binding
phosphatidylinositol binding
SH3 domain binding
superoxide-generating NADPH oxidase activity - Gene Ontology Cellular Component:
- cytosol
extrinsic component of membrane
NADPH oxidase complex
phagolysosome - Keywords:
- 3D-structure
Alternative splicing
Chronic granulomatous disease
Complete proteome
Cytoplasm
Disease mutation
Lipid-binding
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Repeat
SH3 domain - Interacts With:
- Q8IZP0; P60709; P13498; P04899; P19878; Q15080