Names & Taxonomy

Uniprot ID:
P14598
Entry Name:
NCF1_HUMAN
Status:
reviewed
Protein Names:
Neutrophil cytosol factor 1 (NCF-1) (47 kDa autosomal chronic granulomatous disease protein) (47 kDa neutrophil oxidase factor) (NCF-47K) (Neutrophil NADPH oxidase factor 1) (Nox organizer 2) (Nox-organizing protein 2) (SH3 and PX domain-containing protein 1A) (p47-phox)
Gene Names:
NCF1 NOXO2 SH3PXD1A
Gene Names Primary:
NCF1
Organism:
Homo sapiens (Human)

Structure

Length:
390
Sequence:
MGDTFIRHIALLGFEKRFVPSQHYVYMFLVKWQDLSEKVVYRRFTEIYEFHKTLKEMFPIEAGAINPENRIIPHLPAPKWFDGQRAAENRQGTLTEYCGTLMSLPTKISRCPHLLDFFKVRPDDLKLPTDNQTKKPETYLMPKDGKSTATDITGPIILQTYRAIANYEKTSGSEMALSTGDVVEVVEKSESGWWFCQMKAKRGWIPASFLEPLDSPDETEDPEPNYAGEPYVAIKAYTAVEGDEVSLLEGEAVEVIHKLLDGWWVIRKDDVTGYFPSMYLQKSGQDVSQAQRQIKRGAPPRRSSIRNAHSIHQRSRKRLSQDAYRRNSVRFLQQRRRQARPGPQSPGSPLEEERQTQRSKPQPAVPPRPSADLILNRCSESTKRKLASAV
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm, cytosol

Function

Function:
NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).
Cross Reference Drug Bank:
DB00514
Gene Ontology Go:
cytosol
extrinsic component of membrane
NADPH oxidase complex
phagolysosome
electron carrier activity
phosphatidylinositol binding
phosphatidylinositol-3,4-bisphosphate binding
SH3 domain binding
superoxide-generating NADPH oxidase activity
antigen processing and presentation of exogenous peptide antigen via MHC class I
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
antigen processing and presentation of peptide antigen via MHC class I
cell redox homeostasis
cellular defense response
innate immune response
oxidation-reduction process
protein targeting to membrane
respiratory burst
small GTPase mediated signal transduction
superoxide anion generation
superoxide metabolic process
vascular endothelial growth factor receptor signaling pathway
Gene Ontology Biological Process:
antigen processing and presentation of exogenous peptide antigen via MHC class I
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
antigen processing and presentation of peptide antigen via MHC class I
cell redox homeostasis
cellular defense response
innate immune response
oxidation-reduction process
protein targeting to membrane
respiratory burst
small GTPase mediated signal transduction
superoxide anion generation
superoxide metabolic process
vascular endothelial growth factor receptor signaling pathway
Gene Ontology Molecular Function:
electron carrier activity
phosphatidylinositol-3,4-bisphosphate binding
phosphatidylinositol binding
SH3 domain binding
superoxide-generating NADPH oxidase activity
Gene Ontology Cellular Component:
cytosol
extrinsic component of membrane
NADPH oxidase complex
phagolysosome
Keywords:
3D-structure
Alternative splicing
Chronic granulomatous disease
Complete proteome
Cytoplasm
Disease mutation
Lipid-binding
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Repeat
SH3 domain
Interacts With:
Q8IZP0; P60709; P13498; P04899; P19878; Q15080

Publication

PubMed ID:
2550933 2547247 2398896 9329953 10772875 11740866 14702039 12853948 15489334 7581362 2011585 8089108 9224653 12023963 12716910 16052631 19807924 19718658 19801500 11373621 12169629 12356722 12732142 15147273 15657040 16326715 11133775 23910690