Names & Taxonomy
- Uniprot ID:
- P13995
- Entry Name:
- MTDC_HUMAN
- Status:
- reviewed
- Protein Names:
- Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial [Includes: NAD-dependent methylenetetrahydrofolate dehydrogenase (EC 1.5.1.15); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)]
- Gene Names:
- MTHFD2 NMDMC
- Gene Names Primary:
- MTHFD2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 350
- Sequence:
- MAATSLMSALAARLLQPAHSCSLRLRPFHLAAVRNEAVVISGRKLAQQIKQEVRQEVEEWVASGNKRPHLSVILVGENPASHSYVLNKTRAAAVVGINSETIMKPASISEEELLNLINKLNNDDNVDGLLVQLPLPEHIDERRICNAVSPDKDVDGFHVINVGRMCLDQYSMLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTDGAHERPGGDATVTISHRYTPKEQLKKHTILADIVISAAGIPNLITADMIKEGAAVIDVGINRVHDPVTAKPKLVGDVDFEGVRQKAGYITPVPGGVGPMTVAMLMKNTIIAAKKVLRLEEREVLKSKELGVATN
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion.
Function
- Catalytic Activity:
- 5,10-methylenetetrahydrofolate + NAD(+) = 5,10-methenyltetrahydrofolate + NADH.; 5,10-methenyltetrahydrofolate + H(2)O = 10-formyltetrahydrofolate.
- Cofactor:
- COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Cross Reference Drug Bank:
- DB00116
- Gene Ontology Go:
- extracellular space
mitochondrion
magnesium ion binding
methenyltetrahydrofolate cyclohydrolase activity
methylenetetrahydrofolate dehydrogenase (NAD+) activity
methylenetetrahydrofolate dehydrogenase (NADP+) activity
phosphate ion binding
folic acid-containing compound biosynthetic process
one-carbon metabolic process
tetrahydrofolate metabolic process - Gene Ontology Biological Process:
- folic acid-containing compound biosynthetic process
one-carbon metabolic process
tetrahydrofolate metabolic process - Gene Ontology Molecular Function:
- magnesium ion binding
methenyltetrahydrofolate cyclohydrolase activity
methylenetetrahydrofolate dehydrogenase (NAD+) activity
methylenetetrahydrofolate dehydrogenase (NADP+) activity
phosphate ion binding - Gene Ontology Cellular Component:
- extracellular space
mitochondrion - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Complete proteome
Hydrolase
Magnesium
Mitochondrion
Multifunctional enzyme
NAD
One-carbon metabolism
Oxidoreductase
Reference proteome
Transit peptide