Names & Taxonomy

Uniprot ID:
P13995
Entry Name:
MTDC_HUMAN
Status:
reviewed
Protein Names:
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial [Includes: NAD-dependent methylenetetrahydrofolate dehydrogenase (EC 1.5.1.15); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)]
Gene Names:
MTHFD2 NMDMC
Gene Names Primary:
MTHFD2
Organism:
Homo sapiens (Human)

Structure

Length:
350
Sequence:
MAATSLMSALAARLLQPAHSCSLRLRPFHLAAVRNEAVVISGRKLAQQIKQEVRQEVEEWVASGNKRPHLSVILVGENPASHSYVLNKTRAAAVVGINSETIMKPASISEEELLNLINKLNNDDNVDGLLVQLPLPEHIDERRICNAVSPDKDVDGFHVINVGRMCLDQYSMLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTDGAHERPGGDATVTISHRYTPKEQLKKHTILADIVISAAGIPNLITADMIKEGAAVIDVGINRVHDPVTAKPKLVGDVDFEGVRQKAGYITPVPGGVGPMTVAMLMKNTIIAAKKVLRLEEREVLKSKELGVATN
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Mitochondrion.

Function

Catalytic Activity:
5,10-methylenetetrahydrofolate + NAD(+) = 5,10-methenyltetrahydrofolate + NADH.; 5,10-methenyltetrahydrofolate + H(2)O = 10-formyltetrahydrofolate.
Cofactor:
COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Cross Reference Drug Bank:
DB00116
Gene Ontology Go:
extracellular space
mitochondrion
magnesium ion binding
methenyltetrahydrofolate cyclohydrolase activity
methylenetetrahydrofolate dehydrogenase (NAD+) activity
methylenetetrahydrofolate dehydrogenase (NADP+) activity
phosphate ion binding
folic acid-containing compound biosynthetic process
one-carbon metabolic process
tetrahydrofolate metabolic process
Gene Ontology Biological Process:
folic acid-containing compound biosynthetic process
one-carbon metabolic process
tetrahydrofolate metabolic process
Gene Ontology Molecular Function:
magnesium ion binding
methenyltetrahydrofolate cyclohydrolase activity
methylenetetrahydrofolate dehydrogenase (NAD+) activity
methylenetetrahydrofolate dehydrogenase (NADP+) activity
phosphate ion binding
Gene Ontology Cellular Component:
extracellular space
mitochondrion
Keywords:
3D-structure
Acetylation
Alternative splicing
Complete proteome
Hydrolase
Magnesium
Mitochondrion
Multifunctional enzyme
NAD
One-carbon metabolism
Oxidoreductase
Reference proteome
Transit peptide

Publication

PubMed ID:
2587219 14702039 15815621 15489334 19608861 21269460 22814378 25944712