Names & Taxonomy
- Uniprot ID:
- P13945
- Entry Name:
- ADRB3_HUMAN
- Status:
- reviewed
- Protein Names:
- Beta-3 adrenergic receptor (Beta-3 adrenoreceptor) (Beta-3 adrenoceptor)
- Gene Names:
- ADRB3 ADRB3R B3AR
- Gene Names Primary:
- ADRB3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 408
- Sequence:
- MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRGELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLLCRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein.
Function
- Function:
- Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.
- Cross Reference Drug Bank:
- DB00321 DB00182 DB01102 DB00217 DB08807 DB08808 DB01407 DB06262 DB01363 DB00668 DB01288 DB01064 DB01365 DB08893 DB00368 DB00540 DB00334 DB00571 DB00726
- Gene Ontology Go:
- integral component of plasma membrane
nucleus
plasma membrane
receptor complex
beta-adrenergic receptor activity
beta3-adrenergic receptor activity
epinephrine binding
norepinephrine binding
protein homodimerization activity
activation of adenylate cyclase activity
adenylate cyclase-activating adrenergic receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
aging
brown fat cell differentiation
carbohydrate metabolic process
cell-cell signaling
diet induced thermogenesis
eating behavior
energy reserve metabolic process
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
generation of precursor metabolites and energy
heat generation
negative regulation of multicellular organism growth
positive regulation of MAPK cascade
response to antibiotic
response to cold
temperature homeostasis
vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure - Gene Ontology Biological Process:
- activation of adenylate cyclase activity
adenylate cyclase-activating adrenergic receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
aging
brown fat cell differentiation
carbohydrate metabolic process
cell-cell signaling
diet induced thermogenesis
eating behavior
energy reserve metabolic process
generation of precursor metabolites and energy
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
heat generation
negative regulation of multicellular organism growth
positive regulation of MAPK cascade
response to antibiotic
response to cold
temperature homeostasis
vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure - Gene Ontology Molecular Function:
- beta3-adrenergic receptor activity
beta-adrenergic receptor activity
epinephrine binding
norepinephrine binding
protein homodimerization activity - Gene Ontology Cellular Component:
- integral component of plasma membrane
nucleus
plasma membrane
receptor complex - Keywords:
- 3D-structure
Cell membrane
Complete proteome
Diabetes mellitus
Disulfide bond
G-protein coupled receptor
Glycoprotein
Lipoprotein
Membrane
Obesity
Palmitate
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix