Names & Taxonomy

Uniprot ID:
P13639
Entry Name:
EF2_HUMAN
Status:
reviewed
Protein Names:
Elongation factor 2 (EF-2)
Gene Names:
EEF2 EF2
Gene Names Primary:
EEF2
Organism:
Homo sapiens (Human)

Structure

Length:
858
Sequence:
MVNFTVDQIRAIMDKKANIRNMSVIAHVDHGKSTLTDSLVCKAGIIASARAGETRFTDTRKDEQERCITIKSTAISLFYELSENDLNFIKQSKDGAGFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDCVSGVCVQTETVLRQAIAERIKPVLMMNKMDRALLELQLEPEELYQTFQRIVENVNVIISTYGEGESGPMGNIMIDPVLGTVGFGSGLHGWAFTLKQFAEMYVAKFAAKGEGQLGPAERAKKVEDMMKKLWGDRYFDPANGKFSKSATSPEGKKLPRTFCQLILDPIFKVFDAIMNFKKEETAKLIEKLDIKLDSEDKDKEGKPLLKAVMRRWLPAGDALLQMITIHLPSPVTAQKYRCELLYEGPPDDEAAMGIKSCDPKGPLMMYISKMVPTSDKGRFYAFGRVFSGLVSTGLKVRIMGPNYTPGKKEDLYLKPIQRTILMMGRYVEPIEDVPCGNIVGLVGVDQFLVKTGTITTFEHAHNMRVMKFSVSPVVRVAVEAKNPADLPKLVEGLKRLAKSDPMVQCIIEESGEHIIAGAGELHLEICLKDLEEDHACIPIKKSDPVVSYRETVSEESNVLCLSKSPNKHNRLYMKARPFPDGLAEDIDKGEVSARQELKQRARYLAEKYEWDVAEARKIWCFGPDGTGPNILTDITKGVQYLNEIKDSVVAGFQWATKEGALCEENMRGVRFDVHDVTLHADAIHRGGGQIIPTARRCLYASVLTAQPRLMEPIYLVEIQCPEQVVGGIYGVLNRKRGHVFEESQVAGTPMFVVKAYLPVNESFGFTADLRSNTGGQAFPQCVFDHWQILPGDPFDNSSRPSQVVAETRKRKGLKEGIPALDNFLDKL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm. Nucleus

Function

Function:
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
Gene Ontology Go:
aggresome
cytoplasm
cytosol
extracellular exosome
intracellular ribonucleoprotein complex
membrane
membrane raft
nucleus
plasma membrane
polysomal ribosome
5S rRNA binding
GTP binding
GTPase activity
poly(A) RNA binding
protein kinase binding
ribosome binding
translation elongation factor activity
aging
cellular protein metabolic process
cellular response to brain-derived neurotrophic factor stimulus
gene expression
glial cell proliferation
hematopoietic progenitor cell differentiation
peptidyl-diphthamide biosynthetic process from peptidyl-histidine
positive regulation of cytoplasmic translation
positive regulation of translation
post-translational protein modification
response to endoplasmic reticulum stress
response to estradiol
response to ethanol
response to fluoxetine
response to folic acid
response to hydrogen peroxide
response to ischemia
skeletal muscle cell differentiation
skeletal muscle contraction
translation
translational elongation
Gene Ontology Biological Process:
aging
cellular protein metabolic process
cellular response to brain-derived neurotrophic factor stimulus
gene expression
glial cell proliferation
hematopoietic progenitor cell differentiation
peptidyl-diphthamide biosynthetic process from peptidyl-histidine
positive regulation of cytoplasmic translation
positive regulation of translation
post-translational protein modification
response to endoplasmic reticulum stress
response to estradiol
response to ethanol
response to fluoxetine
response to folic acid
response to hydrogen peroxide
response to ischemia
skeletal muscle cell differentiation
skeletal muscle contraction
translation
translational elongation
Gene Ontology Molecular Function:
5S rRNA binding
GTPase activity
GTP binding
poly(A) RNA binding
protein kinase binding
ribosome binding
translation elongation factor activity
Gene Ontology Cellular Component:
aggresome
cytoplasm
cytosol
extracellular exosome
intracellular ribonucleoprotein complex
membrane
membrane raft
nucleus
plasma membrane
polysomal ribosome
Keywords:
3D-structure
Acetylation
Complete proteome
Cytoplasm
Direct protein sequencing
Disease mutation
Elongation factor
GTP-binding
Isopeptide bond
Methylation
Neurodegeneration
Nucleotide-binding
Nucleus
Phosphoprotein
Protein biosynthesis
Reference proteome
Spinocerebellar ataxia
Ubl conjugation
Interacts With:
Q60823

Publication

PubMed ID:
2610926 1596361 15489334 2840927 16139798 17081983 18669648 19413330 19417104 19608861 20068231 21269460 21406692 22223895 22814378 23184662 24648518 25231979 24275569 25944712 23636399 23001565