Names & Taxonomy

Uniprot ID:
P13637
Entry Name:
AT1A3_HUMAN
Status:
reviewed
Protein Names:
Sodium/potassium-transporting ATPase subunit alpha-3 (Na(+)/K(+) ATPase alpha-3 subunit) (EC 3.6.3.9) (Na(+)/K(+) ATPase alpha(III) subunit) (Sodium pump subunit alpha-3)
Gene Names:
ATP1A3
Gene Names Primary:
ATP1A3
Organism:
Homo sapiens (Human)

Structure

Length:
1013
Sequence:
MGDKKDDKDSPKKNKGKERRDLDDLKKEVAMTEHKMSVEEVCRKYNTDCVQGLTHSKAQEILARDGPNALTPPPTTPEWVKFCRQLFGGFSILLWIGAILCFLAYGIQAGTEDDPSGDNLYLGIVLAAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIREGEKMQVNAEEVVVGDLVEIKGGDRVPADLRIISAHGCKVDNSSLTGESEPQTRSPDCTHDNPLETRNITFFSTNCVEGTARGVVVATGDRTVMGRIATLASGLEVGKTPIAIEIEHFIQLITGVAVFLGVSFFILSLILGYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTEDQSGTSFDKSSHTWVALSHIAGLCNRAVFKGGQDNIPVLKRDVAGDASESALLKCIELSSGSVKLMRERNKKVAEIPFNSTNKYQLSIHETEDPNDNRYLLVMKGAPERILDRCSTILLQGKEQPLDEEMKEAFQNAYLELGGLGERVLGFCHYYLPEEQFPKGFAFDCDDVNFTTDNLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVSQVNPRDAKACVIHGTDLKDFTSEQIDEILQNHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLLFIMANIPLPLGTITILCIDLGTDMVPAISLAYEAAESDIMKRQPRNPRTDKLVNERLISMAYGQIGMIQALGGFFSYFVILAENGFLPGNLVGIRLNWDDRTVNDLEDSYGQQWTYEQRKVVEFTCHTAFFVSIVVVQWADLIICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPGMDVALRMYPLKPSWWFCAFPYSFLIFVYDEIRKLILRRNPGGWVEKETYY
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane

Function

Function:
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
Catalytic Activity:
ATP + H(2)O + Na(+)(In) + K(+)(Out) = ADP + phosphate + Na(+)(Out) + K(+)(In).
Active Site:
ACT_SITE 366 366 4-aspartylphosphate intermediate.
Gene Ontology Go:
axon
dendritic spine head
dendritic spine neck
endoplasmic reticulum
extracellular vesicle
Golgi apparatus
integral component of membrane
myelin sheath
nucleus
plasma membrane
sarcolemma
sodium:potassium-exchanging ATPase complex
synapse
ATP binding
chaperone binding
metal ion binding
sodium:potassium-exchanging ATPase activity
sodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potential
steroid hormone binding
adult locomotory behavior
ATP hydrolysis coupled proton transport
cardiac conduction
cardiac muscle contraction
cell communication by electrical coupling involved in cardiac conduction
cellular potassium ion homeostasis
cellular response to steroid hormone stimulus
cellular sodium ion homeostasis
establishment or maintenance of transmembrane electrochemical gradient
ion transmembrane transport
ionotropic glutamate receptor signaling pathway
memory
potassium ion import
regulation of cardiac conduction
response to drug
response to glycoside
sodium ion export from cell
transmembrane transport
visual learning
Gene Ontology Biological Process:
adult locomotory behavior
ATP hydrolysis coupled proton transport
cardiac conduction
cardiac muscle contraction
cell communication by electrical coupling involved in cardiac conduction
cellular potassium ion homeostasis
cellular response to steroid hormone stimulus
cellular sodium ion homeostasis
establishment or maintenance of transmembrane electrochemical gradient
ionotropic glutamate receptor signaling pathway
ion transmembrane transport
memory
potassium ion import
regulation of cardiac conduction
response to drug
response to glycoside
sodium ion export from cell
transmembrane transport
visual learning
Gene Ontology Molecular Function:
ATP binding
chaperone binding
metal ion binding
sodium:potassium-exchanging ATPase activity
sodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potential
steroid hormone binding
Gene Ontology Cellular Component:
axon
dendritic spine head
dendritic spine neck
endoplasmic reticulum
extracellular vesicle
Golgi apparatus
integral component of membrane
myelin sheath
nucleus
plasma membrane
sarcolemma
sodium:potassium-exchanging ATPase complex
synapse
Keywords:
ATP-binding
Alternative splicing
Cell membrane
Complete proteome
Deafness
Disease mutation
Dystonia
Hydrolase
Ion transport
Magnesium
Membrane
Metal-binding
Nucleotide-binding
Parkinsonism
Phosphoprotein
Potassium
Potassium transport
Reference proteome
Sodium
Sodium transport
Sodium/potassium transport
Transmembrane
Transmembrane helix
Transport

Publication

PubMed ID:
2838329 2834163 14702039 15057824 15489334 3030810 3036582 7711835 21269460 15260953 19351654 19652145 22850527 22842232 23409136 24468074