Names & Taxonomy
- Uniprot ID:
- P13637
- Entry Name:
- AT1A3_HUMAN
- Status:
- reviewed
- Protein Names:
- Sodium/potassium-transporting ATPase subunit alpha-3 (Na(+)/K(+) ATPase alpha-3 subunit) (EC 3.6.3.9) (Na(+)/K(+) ATPase alpha(III) subunit) (Sodium pump subunit alpha-3)
- Gene Names:
- ATP1A3
- Gene Names Primary:
- ATP1A3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1013
- Sequence:
- MGDKKDDKDSPKKNKGKERRDLDDLKKEVAMTEHKMSVEEVCRKYNTDCVQGLTHSKAQEILARDGPNALTPPPTTPEWVKFCRQLFGGFSILLWIGAILCFLAYGIQAGTEDDPSGDNLYLGIVLAAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIREGEKMQVNAEEVVVGDLVEIKGGDRVPADLRIISAHGCKVDNSSLTGESEPQTRSPDCTHDNPLETRNITFFSTNCVEGTARGVVVATGDRTVMGRIATLASGLEVGKTPIAIEIEHFIQLITGVAVFLGVSFFILSLILGYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTEDQSGTSFDKSSHTWVALSHIAGLCNRAVFKGGQDNIPVLKRDVAGDASESALLKCIELSSGSVKLMRERNKKVAEIPFNSTNKYQLSIHETEDPNDNRYLLVMKGAPERILDRCSTILLQGKEQPLDEEMKEAFQNAYLELGGLGERVLGFCHYYLPEEQFPKGFAFDCDDVNFTTDNLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVSQVNPRDAKACVIHGTDLKDFTSEQIDEILQNHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLLFIMANIPLPLGTITILCIDLGTDMVPAISLAYEAAESDIMKRQPRNPRTDKLVNERLISMAYGQIGMIQALGGFFSYFVILAENGFLPGNLVGIRLNWDDRTVNDLEDSYGQQWTYEQRKVVEFTCHTAFFVSIVVVQWADLIICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPGMDVALRMYPLKPSWWFCAFPYSFLIFVYDEIRKLILRRNPGGWVEKETYY
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
- Catalytic Activity:
- ATP + H(2)O + Na(+)(In) + K(+)(Out) = ADP + phosphate + Na(+)(Out) + K(+)(In).
- Active Site:
- ACT_SITE 366 366 4-aspartylphosphate intermediate.
- Gene Ontology Go:
- axon
dendritic spine head
dendritic spine neck
endoplasmic reticulum
extracellular vesicle
Golgi apparatus
integral component of membrane
myelin sheath
nucleus
plasma membrane
sarcolemma
sodium:potassium-exchanging ATPase complex
synapse
ATP binding
chaperone binding
metal ion binding
sodium:potassium-exchanging ATPase activity
sodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potential
steroid hormone binding
adult locomotory behavior
ATP hydrolysis coupled proton transport
cardiac conduction
cardiac muscle contraction
cell communication by electrical coupling involved in cardiac conduction
cellular potassium ion homeostasis
cellular response to steroid hormone stimulus
cellular sodium ion homeostasis
establishment or maintenance of transmembrane electrochemical gradient
ion transmembrane transport
ionotropic glutamate receptor signaling pathway
memory
potassium ion import
regulation of cardiac conduction
response to drug
response to glycoside
sodium ion export from cell
transmembrane transport
visual learning - Gene Ontology Biological Process:
- adult locomotory behavior
ATP hydrolysis coupled proton transport
cardiac conduction
cardiac muscle contraction
cell communication by electrical coupling involved in cardiac conduction
cellular potassium ion homeostasis
cellular response to steroid hormone stimulus
cellular sodium ion homeostasis
establishment or maintenance of transmembrane electrochemical gradient
ionotropic glutamate receptor signaling pathway
ion transmembrane transport
memory
potassium ion import
regulation of cardiac conduction
response to drug
response to glycoside
sodium ion export from cell
transmembrane transport
visual learning - Gene Ontology Molecular Function:
- ATP binding
chaperone binding
metal ion binding
sodium:potassium-exchanging ATPase activity
sodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potential
steroid hormone binding - Gene Ontology Cellular Component:
- axon
dendritic spine head
dendritic spine neck
endoplasmic reticulum
extracellular vesicle
Golgi apparatus
integral component of membrane
myelin sheath
nucleus
plasma membrane
sarcolemma
sodium:potassium-exchanging ATPase complex
synapse - Keywords:
- ATP-binding
Alternative splicing
Cell membrane
Complete proteome
Deafness
Disease mutation
Dystonia
Hydrolase
Ion transport
Magnesium
Membrane
Metal-binding
Nucleotide-binding
Parkinsonism
Phosphoprotein
Potassium
Potassium transport
Reference proteome
Sodium
Sodium transport
Sodium/potassium transport
Transmembrane
Transmembrane helix
Transport