Names & Taxonomy
- Uniprot ID:
- P13612
- Entry Name:
- ITA4_HUMAN
- Status:
- reviewed
- Protein Names:
- Integrin alpha-4 (CD49 antigen-like family member D) (Integrin alpha-IV) (VLA-4 subunit alpha) (CD antigen CD49d)
- Gene Names:
- ITGA4 CD49D
- Gene Names Primary:
- ITGA4
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1032
- Sequence:
- MAWEARREPGPRRAAVRETVMLLLCLGVPTGRPYNVDTESALLYQGPHNTLFGYSVVLHSHGANRWLLVGAPTANWLANASVINPGAIYRCRIGKNPGQTCEQLQLGSPNGEPCGKTCLEERDNQWLGVTLSRQPGENGSIVTCGHRWKNIFYIKNENKLPTGGCYGVPPDLRTELSKRIAPCYQDYVKKFGENFASCQAGISSFYTKDLIVMGAPGSSYWTGSLFVYNITTNKYKAFLDKQNQVKFGSYLGYSVGAGHFRSQHTTEVVGGAPQHEQIGKAYIFSIDEKELNILHEMKGKKLGSYFGASVCAVDLNADGFSDLLVGAPMQSTIREEGRVFVYINSGSGAVMNAMETNLVGSDKYAARFGESIVNLGDIDNDGFEDVAIGAPQEDDLQGAIYIYNGRADGISSTFSQRIEGLQISKSLSMFGQSISGQIDADNNGYVDVAVGAFRSDSAVLLRTRPVVIVDASLSHPESVNRTKFDCVENGWPSVCIDLTLCFSYKGKEVPGYIVLFYNMSLDVNRKAESPPRFYFSSNGTSDVITGSIQVSSREANCRTHQAFMRKDVRDILTPIQIEAAYHLGPHVISKRSTEEFPPLQPILQQKKEKDIMKKTINFARFCAHENCSADLQVSAKIGFLKPHENKTYLAVGSMKTLMLNVSLFNAGDDAYETTLHVKLPVGLYFIKILELEEKQINCEVTDNSGVVQLDCSIGYIYVDHLSRIDISFLLDVSSLSRAEEDLSITVHATCENEEEMDNLKHSRVTVAIPLKYEVKLTVHGFVNPTSFVYGSNDENEPETCMVEKMNLTFHVINTGNSMAPNVSVEIMVPNSFSPQTDKLFNILDVQTTTGECHFENYQRVCALEQQKSAMQTLKGIVRFLSKTDKRLLYCIKADPHCLNFLCNFGKMESGKEASVHIQLEGRPSILEMDETSALKFEIRATGFPEPNPRVIELNKDENVAHVLLEGLHHQRPKRYFTIVIISSSLLLGLIVLLLISYVMWKAGFFKRQYKSILQEENRRDSWSYINSKSNDD
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Single-pass type I membrane protein.
Function
- Function:
- Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells.
- Cross Reference Drug Bank:
- DB00108 DB06822 DB09033
- Gene Ontology Go:
- cell surface
extracellular exosome
focal adhesion
integrin alpha4-beta7 complex
membrane
plasma membrane
antigen binding
cell adhesion molecule binding
metal ion binding
B cell differentiation
blood coagulation
cell-matrix adhesion
cell-matrix adhesion involved in ameboidal cell migration
cellular response to cytokine stimulus
clathrin-mediated extracellular exosome endocytosis
diapedesis
endodermal cell differentiation
extracellular matrix organization
heterotypic cell-cell adhesion
import into cell
integrin-mediated signaling pathway
leukocyte cell-cell adhesion
leukocyte migration
leukocyte tethering or rolling
negative regulation of protein homodimerization activity
positive regulation of leukocyte tethering or rolling
positive regulation of T cell migration
receptor clustering
regulation of immune response
substrate adhesion-dependent cell spreading - Gene Ontology Biological Process:
- B cell differentiation
blood coagulation
cell-matrix adhesion
cell-matrix adhesion involved in ameboidal cell migration
cellular response to cytokine stimulus
clathrin-mediated extracellular exosome endocytosis
diapedesis
endodermal cell differentiation
extracellular matrix organization
heterotypic cell-cell adhesion
import into cell
integrin-mediated signaling pathway
leukocyte cell-cell adhesion
leukocyte migration
leukocyte tethering or rolling
negative regulation of protein homodimerization activity
positive regulation of leukocyte tethering or rolling
positive regulation of T cell migration
receptor clustering
regulation of immune response
substrate adhesion-dependent cell spreading - Gene Ontology Molecular Function:
- antigen binding
cell adhesion molecule binding
metal ion binding - Gene Ontology Cellular Component:
- cell surface
extracellular exosome
focal adhesion
integrin alpha4-beta7 complex
membrane
plasma membrane - Keywords:
- 3D-structure
Alternative splicing
Calcium
Cell adhesion
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
Integrin
Membrane
Metal-binding
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix - Interacts With:
- P05556; P26010; P49023; O43294