Names & Taxonomy
- Uniprot ID:
- P13584
- Entry Name:
- CP4B1_HUMAN
- Status:
- reviewed
- Protein Names:
- Cytochrome P450 4B1 (EC 1.14.14.1) (CYPIVB1) (Cytochrome P450-HP)
- Gene Names:
- CYP4B1
- Gene Names Primary:
- CYP4B1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 511
- Sequence:
- MVPSFLSLSFSSLGLWASGLILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALEIQETGSLDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDVYDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKMPQLVLRSKNGFHLHLKPLGPGSGK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Function
- Function:
- Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
- Catalytic Activity:
- RH + + O(2) = ROH + + H(2)O.
- Cofactor:
- COFACTOR: Name=heme; Xref=ChEBI:CHEBI:30413;
- Cross Reference Drug Bank:
- DB00683 DB01174 DB00152
- Gene Ontology Go:
- endoplasmic reticulum membrane
aromatase activity
drug binding
fluorene oxygenase activity
heme binding
iron ion binding
oxygen binding
toxic substance binding
biphenyl metabolic process
exogenous drug catabolic process
fluorene metabolic process
small molecule metabolic process
xenobiotic metabolic process - Gene Ontology Biological Process:
- biphenyl metabolic process
exogenous drug catabolic process
fluorene metabolic process
small molecule metabolic process
xenobiotic metabolic process - Gene Ontology Molecular Function:
- aromatase activity
drug binding
fluorene oxygenase activity
heme binding
iron ion binding
oxygen binding
toxic substance binding - Gene Ontology Cellular Component:
- endoplasmic reticulum membrane
- Keywords:
- Alternative splicing
Complete proteome
Endoplasmic reticulum
Heme
Iron
Membrane
Metal-binding
Microsome
Monooxygenase
Oxidoreductase
Polymorphism
Reference proteome