Names & Taxonomy
- Uniprot ID:
- P13500
- Entry Name:
- CCL2_HUMAN
- Status:
- reviewed
- Protein Names:
- C-C motif chemokine 2 (HC11) (Monocyte chemoattractant protein 1) (Monocyte chemotactic and activating factor) (MCAF) (Monocyte chemotactic protein 1) (MCP-1) (Monocyte secretory protein JE) (Small-inducible cytokine A2)
- Gene Names:
- CCL2 MCP1 SCYA2
- Gene Names Primary:
- CCL2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 99
- Sequence:
- MKVSAALLCLLLIAATFIPQGLAQPDAINAPVTCCYNFTNRKISVQRLASYRRITSSKCPKEAVIFKTIVAKEICADPKQKWVQDSMDHLDKQTQTPKT
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted.
Function
- Function:
- Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis.
- Cross Reference Drug Bank:
- DB01406 DB01055
- Gene Ontology Go:
- axon terminus
C-fiber
dendrite
endocytic vesicle
extracellular region
extracellular space
perikaryon
perinuclear region of cytoplasm
rough endoplasmic reticulum
synapse
CCR2 chemokine receptor binding
chemokine activity
heparin binding
protein kinase activity
receptor binding
aging
angiogenesis
astrocyte cell migration
cell adhesion
cell surface receptor signaling pathway
cellular calcium ion homeostasis
cellular homeostasis
cellular protein metabolic process
cellular response to ATP
cellular response to dexamethasone stimulus
cellular response to drug
cellular response to fibroblast growth factor stimulus
cellular response to high density lipoprotein particle stimulus
cellular response to insulin stimulus
cellular response to interferon-gamma
cellular response to interleukin-1
cellular response to interleukin-6
cellular response to lipopolysaccharide
cellular response to macrophage colony-stimulating factor stimulus
cellular response to organic cyclic compound
cellular response to platelet-derived growth factor stimulus
cellular response to retinoic acid
cellular response to tumor necrosis factor
chemokine-mediated signaling pathway
chemotaxis
cytokine-mediated signaling pathway
cytoskeleton organization
endoplasmic reticulum unfolded protein response
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
helper T cell extravasation
humoral immune response
inflammatory response
JAK-STAT cascade
leukocyte migration involved in inflammatory response
lipopolysaccharide-mediated signaling pathway
lymphocyte chemotaxis
macrophage chemotaxis
MAPK cascade
maternal process involved in female pregnancy
maternal process involved in parturition
monocyte chemotaxis
negative regulation of angiogenesis
negative regulation of glial cell apoptotic process
negative regulation of natural killer cell chemotaxis
negative regulation of neuron apoptotic process
neutrophil chemotaxis
organ morphogenesis
organ regeneration
PERK-mediated unfolded protein response
positive regulation of apoptotic cell clearance
positive regulation of calcium ion import
positive regulation of cellular extravasation
positive regulation of collagen biosynthetic process
positive regulation of endothelial cell proliferation
positive regulation of ERK1 and ERK2 cascade
positive regulation of GTPase activity
positive regulation of immune complex clearance by monocytes and macrophages
positive regulation of inflammatory response
positive regulation of leukocyte mediated cytotoxicity
positive regulation of macrophage chemotaxis
positive regulation of monocyte chemotaxis
positive regulation of nitric-oxide synthase biosynthetic process
positive regulation of protein targeting to membrane
positive regulation of synaptic transmission
positive regulation of T cell activation
positive regulation of tumor necrosis factor production
protein kinase B signaling
protein phosphorylation
regulation of cell shape
regulation of vascular endothelial growth factor production
response to activity
response to amino acid
response to antibiotic
response to bacterium
response to ethanol
response to gamma radiation
response to heat
response to hypoxia
response to mechanical stimulus
response to progesterone
response to vitamin B3
response to wounding
signal transduction
transforming growth factor beta receptor signaling pathway
vascular endothelial growth factor receptor signaling pathway
viral genome replication - Gene Ontology Biological Process:
- aging
angiogenesis
astrocyte cell migration
cell adhesion
cell surface receptor signaling pathway
cellular calcium ion homeostasis
cellular homeostasis
cellular protein metabolic process
cellular response to ATP
cellular response to dexamethasone stimulus
cellular response to drug
cellular response to fibroblast growth factor stimulus
cellular response to high density lipoprotein particle stimulus
cellular response to insulin stimulus
cellular response to interferon-gamma
cellular response to interleukin-1
cellular response to interleukin-6
cellular response to lipopolysaccharide
cellular response to macrophage colony-stimulating factor stimulus
cellular response to organic cyclic compound
cellular response to platelet-derived growth factor stimulus
cellular response to retinoic acid
cellular response to tumor necrosis factor
chemokine-mediated signaling pathway
chemotaxis
cytokine-mediated signaling pathway
cytoskeleton organization
endoplasmic reticulum unfolded protein response
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
helper T cell extravasation
humoral immune response
inflammatory response
JAK-STAT cascade
leukocyte migration involved in inflammatory response
lipopolysaccharide-mediated signaling pathway
lymphocyte chemotaxis
macrophage chemotaxis
MAPK cascade
maternal process involved in female pregnancy
maternal process involved in parturition
monocyte chemotaxis
negative regulation of angiogenesis
negative regulation of glial cell apoptotic process
negative regulation of natural killer cell chemotaxis
negative regulation of neuron apoptotic process
neutrophil chemotaxis
organ morphogenesis
organ regeneration
PERK-mediated unfolded protein response
positive regulation of apoptotic cell clearance
positive regulation of calcium ion import
positive regulation of cellular extravasation
positive regulation of collagen biosynthetic process
positive regulation of endothelial cell proliferation
positive regulation of ERK1 and ERK2 cascade
positive regulation of GTPase activity
positive regulation of immune complex clearance by monocytes and macrophages
positive regulation of inflammatory response
positive regulation of leukocyte mediated cytotoxicity
positive regulation of macrophage chemotaxis
positive regulation of monocyte chemotaxis
positive regulation of nitric-oxide synthase biosynthetic process
positive regulation of protein targeting to membrane
positive regulation of synaptic transmission
positive regulation of T cell activation
positive regulation of tumor necrosis factor production
protein kinase B signaling
protein phosphorylation
regulation of cell shape
regulation of vascular endothelial growth factor production
response to activity
response to amino acid
response to antibiotic
response to bacterium
response to ethanol
response to gamma radiation
response to heat
response to hypoxia
response to mechanical stimulus
response to progesterone
response to vitamin B3
response to wounding
signal transduction
transforming growth factor beta receptor signaling pathway
vascular endothelial growth factor receptor signaling pathway
viral genome replication - Gene Ontology Molecular Function:
- CCR2 chemokine receptor binding
chemokine activity
heparin binding
protein kinase activity
receptor binding - Gene Ontology Cellular Component:
- axon terminus
C-fiber
dendrite
endocytic vesicle
extracellular region
extracellular space
perikaryon
perinuclear region of cytoplasm
rough endoplasmic reticulum
synapse - Keywords:
- 3D-structure
Chemotaxis
Complete proteome
Cytokine
Direct protein sequencing
Disulfide bond
Glycoprotein
Inflammatory response
Pyrrolidone carboxylic acid
Reference proteome
Secreted
Signal