Names & Taxonomy
- Uniprot ID:
- P13498
- Entry Name:
- CY24A_HUMAN
- Status:
- reviewed
- Protein Names:
- Cytochrome b-245 light chain (Cytochrome b(558) alpha chain) (Cytochrome b558 subunit alpha) (Neutrophil cytochrome b 22 kDa polypeptide) (Superoxide-generating NADPH oxidase light chain subunit) (p22 phagocyte B-cytochrome) (p22-phox) (p22phox)
- Gene Names:
- CYBA
- Gene Names Primary:
- CYBA
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 195
- Sequence:
- MGQIEWAMWANEQALASGLILITGGIVATAGRFTQWYFGAYSIVAGVFVCLLEYPRGKRKKGSTMERWGQKYMTAVVKLFGPFTRNYYVRAVLHLLLSVPAGFLLATILGTACLAIASGIYLLAAVRGEQWTPIEPKPRERPQIGGTIKQPPSNPPPRPPAEARKKPSEEEAAVAAGGPPGGPQVNPIPVTDEVV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
- Intramembrane:
- INTRAMEM 91 127
Function
- Function:
- Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide.
- Cross Reference Drug Bank:
- DB00514
- Gene Ontology Go:
- apical plasma membrane
dendrite
endosome
Golgi apparatus
membrane
mitochondrion
NADPH oxidase complex
neuronal cell body
perinuclear endoplasmic reticulum
phagocytic vesicle membrane
plasma membrane
secretory granule
electron carrier activity
heme binding
metal ion binding
protein heterodimerization activity
SH3 domain binding
superoxide-generating NADPH oxidase activity
antigen processing and presentation of exogenous peptide antigen via MHC class I
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
antigen processing and presentation of peptide antigen via MHC class I
cell redox homeostasis
cellular response to amino acid stimulus
cellular response to gamma radiation
cellular response to glucose stimulus
cellular response to mechanical stimulus
cellular response to organic cyclic compound
cellular response to tumor necrosis factor
cytochrome complex assembly
hydrogen peroxide biosynthetic process
inflammatory response
innate immune response
negative regulation of glomerular filtration by angiotensin
oxidation-reduction process
positive regulation of cell growth
positive regulation of defense response to bacterium
positive regulation of endothelial cell proliferation
positive regulation of interleukin-6 production
positive regulation of mucus secretion
positive regulation of phagocytosis
positive regulation of reactive oxygen species biosynthetic process
positive regulation of smooth muscle cell proliferation
positive regulation of superoxide anion generation
positive regulation of toll-like receptor 2 signaling pathway
positive regulation of tumor necrosis factor production
regulation of release of sequestered calcium ion into cytosol
respiratory burst
response to drug
response to interleukin-1
response to nutrient levels
small GTPase mediated signal transduction
smooth muscle hypertrophy
superoxide anion generation
superoxide metabolic process
vascular endothelial growth factor receptor signaling pathway - Gene Ontology Biological Process:
- antigen processing and presentation of exogenous peptide antigen via MHC class I
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
antigen processing and presentation of peptide antigen via MHC class I
cell redox homeostasis
cellular response to amino acid stimulus
cellular response to gamma radiation
cellular response to glucose stimulus
cellular response to mechanical stimulus
cellular response to organic cyclic compound
cellular response to tumor necrosis factor
cytochrome complex assembly
hydrogen peroxide biosynthetic process
inflammatory response
innate immune response
negative regulation of glomerular filtration by angiotensin
oxidation-reduction process
positive regulation of cell growth
positive regulation of defense response to bacterium
positive regulation of endothelial cell proliferation
positive regulation of interleukin-6 production
positive regulation of mucus secretion
positive regulation of phagocytosis
positive regulation of reactive oxygen species biosynthetic process
positive regulation of smooth muscle cell proliferation
positive regulation of superoxide anion generation
positive regulation of toll-like receptor 2 signaling pathway
positive regulation of tumor necrosis factor production
regulation of release of sequestered calcium ion into cytosol
respiratory burst
response to drug
response to interleukin-1
response to nutrient levels
small GTPase mediated signal transduction
smooth muscle hypertrophy
superoxide anion generation
superoxide metabolic process
vascular endothelial growth factor receptor signaling pathway - Gene Ontology Molecular Function:
- electron carrier activity
heme binding
metal ion binding
protein heterodimerization activity
SH3 domain binding
superoxide-generating NADPH oxidase activity - Gene Ontology Cellular Component:
- apical plasma membrane
dendrite
endosome
Golgi apparatus
membrane
mitochondrion
NADPH oxidase complex
neuronal cell body
perinuclear endoplasmic reticulum
phagocytic vesicle membrane
plasma membrane
secretory granule - Keywords:
- 3D-structure
Cell membrane
Chronic granulomatous disease
Complete proteome
Direct protein sequencing
Disease mutation
Electron transport
Heme
Iron
Membrane
Metal-binding
NADP
Oxidoreductase
Phosphoprotein
Polymorphism
Reference proteome
Transport - Interacts With:
- P14598; Q8NFA2