Names & Taxonomy
- Uniprot ID:
- P13051
- Entry Name:
- UNG_HUMAN
- Status:
- reviewed
- Protein Names:
- Uracil-DNA glycosylase (UDG) (EC 3.2.2.27)
- Gene Names:
- UNG DGU UNG1 UNG15
- Gene Names Primary:
- UNG
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 313
- Sequence:
- MIGQKTLYSFFSPSPARKRHAPSPEPAVQGTGVAGVPEESGDAAAIPAKKAPAGQEEPGTPPSSPLSAEQLDRIQRNKAAALLRLAARNVPVGFGESWKKHLSGEFGKPYFIKLMGFVAEERKHYTVYPPPHQVFTWTQMCDIKDVKVVILGQDPYHGPNQAHGLCFSVQRPVPPPPSLENIYKELSTDIEDFVHPGHGDLSGWAKQGVLLLNAVLTVRAHQANSHKERGWEQFTDAVVSWLNQNSNGLVFLLWGSYAQKKGSAIDRKRHHVLQTAHPSPLSVYRGFFGCRHFSKTNELLQKSGKKPIDWKEL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Isoform 1: Mitochondrion.; Isoform 2: Nucleus.
Function
- Function:
- Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
- Catalytic Activity:
- Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.
- Active Site:
- ACT_SITE 154 154 Proton acceptor.
- Gene Ontology Go:
- mitochondrion
nucleoplasm
nucleus
damaged DNA binding
uracil DNA N-glycosylase activity
base-excision repair
base-excision repair, AP site formation
depyrimidination
DNA repair
negative regulation of apoptotic process
positive regulation of isotype switching
somatic hypermutation of immunoglobulin genes
somatic recombination of immunoglobulin gene segments
viral process - Gene Ontology Biological Process:
- base-excision repair
base-excision repair, AP site formation
depyrimidination
DNA repair
negative regulation of apoptotic process
positive regulation of isotype switching
somatic hypermutation of immunoglobulin genes
somatic recombination of immunoglobulin gene segments
viral process - Gene Ontology Molecular Function:
- damaged DNA binding
uracil DNA N-glycosylase activity - Gene Ontology Cellular Component:
- mitochondrion
nucleoplasm
nucleus - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Complete proteome
DNA damage
DNA repair
Direct protein sequencing
Disease mutation
Glycosidase
Host-virus interaction
Hydrolase
Mitochondrion
Nucleus
Phosphoprotein
Polymorphism
Reference proteome - Interacts With:
- P15927