Names & Taxonomy
- Uniprot ID:
- P12429
- Entry Name:
- ANXA3_HUMAN
- Status:
- reviewed
- Protein Names:
- Annexin A3 (35-alpha calcimedin) (Annexin III) (Annexin-3) (Inositol 1,2-cyclic phosphate 2-phosphohydrolase) (Lipocortin III) (Placental anticoagulant protein III) (PAP-III)
- Gene Names:
- ANXA3 ANX3
- Gene Names Primary:
- ANXA3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 323
- Sequence:
- MASIWVGHRGTVRDYPDFSPSVDAEAIQKAIRGIGTDEKMLISILTERSNAQRQLIVKEYQAAYGKELKDDLKGDLSGHFEHLMVALVTPPAVFDAKQLKKSMKGAGTNEDALIEILTTRTSRQMKDISQAYYTVYKKSLGDDISSETSGDFRKALLTLADGRRDESLKVDEHLAKQDAQILYKAGENRWGTDEDKFTEILCLRSFPQLKLTFDEYRNISQKDIVDSIKGELSGHFEDLLLAIVNCVRNTPAFLAERLHRALKGIGTDEFTLNRIMVSRSEIDLLDIRTEFKKHYGYSLYSAIKSDTSGDYEITLLKICGGDD
- Proteomes:
- UP000005640
Function
- Function:
- Inhibitor of phospholipase A2, also possesses anti-coagulant properties. Also cleaves the cyclic bond of inositol 1,2-cyclic phosphate to form inositol 1-phosphate.
- Gene Ontology Go:
- axon
cytoplasm
dendrite
extracellular exosome
membrane
neuronal cell body
phagocytic vesicle membrane
plasma membrane
specific granule
calcium ion binding
calcium-dependent phospholipid binding
calcium-dependent protein binding
phospholipase A2 inhibitor activity
defense response to bacterium
hippocampus development
neutrophil degranulation
organ regeneration
phagocytosis
positive regulation of angiogenesis
positive regulation of DNA metabolic process
positive regulation of endothelial cell migration
positive regulation of sequence-specific DNA binding transcription factor activity
response to glucocorticoid
response to growth factor - Gene Ontology Biological Process:
- defense response to bacterium
hippocampus development
neutrophil degranulation
organ regeneration
phagocytosis
positive regulation of angiogenesis
positive regulation of DNA metabolic process
positive regulation of endothelial cell migration
positive regulation of sequence-specific DNA binding transcription factor activity
response to glucocorticoid
response to growth factor - Gene Ontology Molecular Function:
- calcium-dependent phospholipid binding
calcium-dependent protein binding
calcium ion binding
phospholipase A2 inhibitor activity - Gene Ontology Cellular Component:
- axon
cytoplasm
dendrite
extracellular exosome
membrane
neuronal cell body
phagocytic vesicle membrane
plasma membrane
specific granule - Keywords:
- 3D-structure
Acetylation
Annexin
Calcium
Calcium/phospholipid-binding
Complete proteome
Direct protein sequencing
Phospholipase A2 inhibitor
Phosphoprotein
Polymorphism
Reference proteome
Repeat