Names & Taxonomy

Uniprot ID:
P12429
Entry Name:
ANXA3_HUMAN
Status:
reviewed
Protein Names:
Annexin A3 (35-alpha calcimedin) (Annexin III) (Annexin-3) (Inositol 1,2-cyclic phosphate 2-phosphohydrolase) (Lipocortin III) (Placental anticoagulant protein III) (PAP-III)
Gene Names:
ANXA3 ANX3
Gene Names Primary:
ANXA3
Organism:
Homo sapiens (Human)

Structure

Length:
323
Sequence:
MASIWVGHRGTVRDYPDFSPSVDAEAIQKAIRGIGTDEKMLISILTERSNAQRQLIVKEYQAAYGKELKDDLKGDLSGHFEHLMVALVTPPAVFDAKQLKKSMKGAGTNEDALIEILTTRTSRQMKDISQAYYTVYKKSLGDDISSETSGDFRKALLTLADGRRDESLKVDEHLAKQDAQILYKAGENRWGTDEDKFTEILCLRSFPQLKLTFDEYRNISQKDIVDSIKGELSGHFEDLLLAIVNCVRNTPAFLAERLHRALKGIGTDEFTLNRIMVSRSEIDLLDIRTEFKKHYGYSLYSAIKSDTSGDYEITLLKICGGDD
Proteomes:
UP000005640

Function

Function:
Inhibitor of phospholipase A2, also possesses anti-coagulant properties. Also cleaves the cyclic bond of inositol 1,2-cyclic phosphate to form inositol 1-phosphate.
Gene Ontology Go:
axon
cytoplasm
dendrite
extracellular exosome
membrane
neuronal cell body
phagocytic vesicle membrane
plasma membrane
specific granule
calcium ion binding
calcium-dependent phospholipid binding
calcium-dependent protein binding
phospholipase A2 inhibitor activity
defense response to bacterium
hippocampus development
neutrophil degranulation
organ regeneration
phagocytosis
positive regulation of angiogenesis
positive regulation of DNA metabolic process
positive regulation of endothelial cell migration
positive regulation of sequence-specific DNA binding transcription factor activity
response to glucocorticoid
response to growth factor
Gene Ontology Biological Process:
defense response to bacterium
hippocampus development
neutrophil degranulation
organ regeneration
phagocytosis
positive regulation of angiogenesis
positive regulation of DNA metabolic process
positive regulation of endothelial cell migration
positive regulation of sequence-specific DNA binding transcription factor activity
response to glucocorticoid
response to growth factor
Gene Ontology Molecular Function:
calcium-dependent phospholipid binding
calcium-dependent protein binding
calcium ion binding
phospholipase A2 inhibitor activity
Gene Ontology Cellular Component:
axon
cytoplasm
dendrite
extracellular exosome
membrane
neuronal cell body
phagocytic vesicle membrane
plasma membrane
specific granule
Keywords:
3D-structure
Acetylation
Annexin
Calcium
Calcium/phospholipid-binding
Complete proteome
Direct protein sequencing
Phospholipase A2 inhibitor
Phosphoprotein
Polymorphism
Reference proteome
Repeat

Publication

PubMed ID:
2968983 1830024 8276419 14702039 15489334 12665801 2159184 2975506 2138632 21269460 8639653 10391209