Names & Taxonomy
- Uniprot ID:
- P12319
- Entry Name:
- FCERA_HUMAN
- Status:
- reviewed
- Protein Names:
- High affinity immunoglobulin epsilon receptor subunit alpha (Fc-epsilon RI-alpha) (FcERI) (IgE Fc receptor subunit alpha)
- Gene Names:
- FCER1A FCE1A
- Gene Names Primary:
- FCER1A
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 257
- Sequence:
- MAPAMESPTLLCVALLFFAPDGVLAVPQKPKVSLNPPWNRIFKGENVTLTCNGNNFFEVSSTKWFHNGSLSEETNSSLNIVNAKFEDSGEYKCQHQQVNESEPVYLEVFSDWLLLQASAEVVMEGQPLFLRCHGWRNWDVYKVIYYKDGEALKYWYENHNISITNATVEDSGTYYCTGKVWQLDYESEPLNITVIKAPREKYWLQFFIPLLVVILFAVDTGLFISTQQQVTFLLKIKRTRKGFRLLNPHPKPNPKNN
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Single-pass type I membrane protein.
Function
- Function:
- Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines.
- Cross Reference Drug Bank:
- DB00895 DB00043
- Gene Ontology Go:
- cell surface
external side of plasma membrane
integral component of plasma membrane
intracellular
plasma membrane
IgE receptor activity
activation of JUN kinase activity
Fc-epsilon receptor signaling pathway
innate immune response
leukotriene biosynthetic process
positive regulation of calcium-mediated signaling
positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process
positive regulation of interleukin-3 biosynthetic process
positive regulation of mast cell degranulation
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of type I hypersensitivity
serotonin secretion - Gene Ontology Biological Process:
- activation of JUN kinase activity
Fc-epsilon receptor signaling pathway
innate immune response
leukotriene biosynthetic process
positive regulation of calcium-mediated signaling
positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process
positive regulation of interleukin-3 biosynthetic process
positive regulation of mast cell degranulation
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of type I hypersensitivity
serotonin secretion - Gene Ontology Molecular Function:
- IgE receptor activity
- Gene Ontology Cellular Component:
- cell surface
external side of plasma membrane
integral component of plasma membrane
intracellular
plasma membrane - Keywords:
- 3D-structure
Cell membrane
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
IgE-binding protein
Immunoglobulin domain
Membrane
Polymorphism
Receptor
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix