Names & Taxonomy
- Uniprot ID:
- P12314
- Entry Name:
- FCGR1_HUMAN
- Status:
- reviewed
- Protein Names:
- High affinity immunoglobulin gamma Fc receptor I (IgG Fc receptor I) (Fc-gamma RI) (FcRI) (Fc-gamma RIA) (FcgammaRIa) (CD antigen CD64)
- Gene Names:
- FCGR1A FCG1 FCGR1 IGFR1
- Gene Names Primary:
- FCGR1A
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 374
- Sequence:
- MWFLTTLLLWVPVDGQVDTTKAVITLQPPWVSVFQEETVTLHCEVLHLPGSSSTQWFLNGTATQTSTPSYRITSASVNDSGEYRCQRGLSGRSDPIQLEIHRGWLLLQVSSRVFTEGEPLALRCHAWKDKLVYNVLYYRNGKAFKFFHWNSNLTILKTNISHNGTYHCSGMGKHRYTSAGISVTVKELFPAPVLNASVTSPLLEGNLVTLSCETKLLLQRPGLQLYFSFYMGSKTLRGRNTSSEYQILTARREDSGLYWCEAATEDGNVLKRSPELELQVLGLQLPTPVWFHVLFYLAVGIMFLVNTVLWVTIRKELKRKKKWDLEISLDSGHEKKVISSLQEDRHLEEELKCQEQKEEQLQEGVHRKEPQGAT
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses.
- Cross Reference Drug Bank:
- DB00054 DB00051 DB00092 DB00087 DB00074 DB00112 DB00002 DB00111 DB00095 DB00005 DB00056 DB00078 DB00028 DB00992 DB00075 DB00108 DB00110 DB00707 DB00073 DB00081 DB00072
- Gene Ontology Go:
- clathrin-coated endocytic vesicle membrane
early endosome membrane
integral component of membrane
plasma membrane
receptor signaling protein activity
antigen processing and presentation of exogenous peptide antigen via MHC class I
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
antigen processing and presentation of peptide antigen via MHC class I
cytokine-mediated signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
immune response
innate immune response
interferon-gamma-mediated signaling pathway
phagocytosis, engulfment
regulation of immune response
signal transduction - Gene Ontology Biological Process:
- antigen processing and presentation of exogenous peptide antigen via MHC class I
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
antigen processing and presentation of peptide antigen via MHC class I
cytokine-mediated signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
immune response
innate immune response
interferon-gamma-mediated signaling pathway
phagocytosis, engulfment
regulation of immune response
signal transduction - Gene Ontology Molecular Function:
- receptor signaling protein activity
- Gene Ontology Cellular Component:
- clathrin-coated endocytic vesicle membrane
early endosome membrane
integral component of membrane
plasma membrane - Keywords:
- 3D-structure
Alternative splicing
Cell membrane
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
IgG-binding protein
Immunity
Immunoglobulin domain
Innate immunity
Membrane
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix