Names & Taxonomy

Uniprot ID:
P12314
Entry Name:
FCGR1_HUMAN
Status:
reviewed
Protein Names:
High affinity immunoglobulin gamma Fc receptor I (IgG Fc receptor I) (Fc-gamma RI) (FcRI) (Fc-gamma RIA) (FcgammaRIa) (CD antigen CD64)
Gene Names:
FCGR1A FCG1 FCGR1 IGFR1
Gene Names Primary:
FCGR1A
Organism:
Homo sapiens (Human)

Structure

Length:
374
Sequence:
MWFLTTLLLWVPVDGQVDTTKAVITLQPPWVSVFQEETVTLHCEVLHLPGSSSTQWFLNGTATQTSTPSYRITSASVNDSGEYRCQRGLSGRSDPIQLEIHRGWLLLQVSSRVFTEGEPLALRCHAWKDKLVYNVLYYRNGKAFKFFHWNSNLTILKTNISHNGTYHCSGMGKHRYTSAGISVTVKELFPAPVLNASVTSPLLEGNLVTLSCETKLLLQRPGLQLYFSFYMGSKTLRGRNTSSEYQILTARREDSGLYWCEAATEDGNVLKRSPELELQVLGLQLPTPVWFHVLFYLAVGIMFLVNTVLWVTIRKELKRKKKWDLEISLDSGHEKKVISSLQEDRHLEEELKCQEQKEEQLQEGVHRKEPQGAT
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane

Function

Function:
High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses.
Cross Reference Drug Bank:
DB00054 DB00051 DB00092 DB00087 DB00074 DB00112 DB00002 DB00111 DB00095 DB00005 DB00056 DB00078 DB00028 DB00992 DB00075 DB00108 DB00110 DB00707 DB00073 DB00081 DB00072
Gene Ontology Go:
clathrin-coated endocytic vesicle membrane
early endosome membrane
integral component of membrane
plasma membrane
receptor signaling protein activity
antigen processing and presentation of exogenous peptide antigen via MHC class I
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
antigen processing and presentation of peptide antigen via MHC class I
cytokine-mediated signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
immune response
innate immune response
interferon-gamma-mediated signaling pathway
phagocytosis, engulfment
regulation of immune response
signal transduction
Gene Ontology Biological Process:
antigen processing and presentation of exogenous peptide antigen via MHC class I
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
antigen processing and presentation of peptide antigen via MHC class I
cytokine-mediated signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
immune response
innate immune response
interferon-gamma-mediated signaling pathway
phagocytosis, engulfment
regulation of immune response
signal transduction
Gene Ontology Molecular Function:
receptor signaling protein activity
Gene Ontology Cellular Component:
clathrin-coated endocytic vesicle membrane
early endosome membrane
integral component of membrane
plasma membrane
Keywords:
3D-structure
Alternative splicing
Cell membrane
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
IgG-binding protein
Immunity
Immunoglobulin domain
Innate immunity
Membrane
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix

Publication

PubMed ID:
2974947 2911749 1430234 1402657 16710414 15340161 1379234 8064233 8611682 9881690 10397749 10514529 10781611 12756162 15229321 18322202 18023480 19159218 21965667