Names & Taxonomy
- Uniprot ID:
- P12271
- Entry Name:
- RLBP1_HUMAN
- Status:
- reviewed
- Protein Names:
- Retinaldehyde-binding protein 1 (Cellular retinaldehyde-binding protein)
- Gene Names:
- RLBP1 CRALBP
- Gene Names Primary:
- RLBP1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 317
- Sequence:
- MSEGVGTFRMVPEEEQELRAQLEQLTTKDHGPVFGPCSQLPRHTLQKAKDELNEREETREEAVRELQEMVQAQAASGEELAVAVAERVQEKDSGFFLRFIRARKFNVGRAYELLRGYVNFRLQYPELFDSLSPEAVRCTIEAGYPGVLSSRDKYGRVVMLFNIENWQSQEITFDEILQAYCFILEKLLENEETQINGFCIIENFKGFTMQQAASLRTSDLRKMVDMLQDSFPARFKAIHFIHQPWYFTTTYNVVKPFLKSKLLERVFVHGDDLSGFYQEIDENILPSDFGGTLPKYDGKAVAEQLFGPQAQAENTAF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Function:
- Soluble retinoid carrier essential the proper function of both rod and cone photoreceptors. Participates in the regeneration of active 11-cis-retinol and 11-cis-retinaldehyde, from the inactive 11-trans products of the rhodopsin photocycle and in the de novo synthesis of these retinoids from 11-trans metabolic precursors. The cycling of retinoids between photoreceptor and adjacent pigment epithelium cells is known as the 'visual cycle'.
- Cross Reference Drug Bank:
- DB00162
- Gene Ontology Go:
- cell body
cytosol
11-cis retinal binding
retinol binding
transporter activity
phototransduction, visible light
retinoid metabolic process
visual perception
vitamin A metabolic process - Gene Ontology Biological Process:
- phototransduction, visible light
retinoid metabolic process
visual perception
vitamin A metabolic process - Gene Ontology Molecular Function:
- 11-cis retinal binding
retinol binding
transporter activity - Gene Ontology Cellular Component:
- cell body
cytosol - Keywords:
- 3D-structure
Acetylation
Complete proteome
Cytoplasm
Disease mutation
Reference proteome
Retinol-binding
Sensory transduction
Transport
Vision