Names & Taxonomy
- Uniprot ID:
- P11766
- Entry Name:
- ADHX_HUMAN
- Status:
- reviewed
- Protein Names:
- Alcohol dehydrogenase class-3 (EC 1.1.1.1) (Alcohol dehydrogenase 5) (Alcohol dehydrogenase class chi chain) (Alcohol dehydrogenase class-III) (Glutathione-dependent formaldehyde dehydrogenase) (FALDH) (FDH) (GSH-FDH) (EC 1.1.1.-) (S-(hydroxymethyl)glutathione dehydrogenase) (EC 1.1.1.284)
- Gene Names:
- ADH5 ADHX FDH
- Gene Names Primary:
- ADH5
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 374
- Sequence:
- MANEVIKCKAAVAWEAGKPLSIEEIEVAPPKAHEVRIKIIATAVCHTDAYTLSGADPEGCFPVILGHEGAGIVESVGEGVTKLKAGDTVIPLYIPQCGECKFCLNPKTNLCQKIRVTQGKGLMPDGTSRFTCKGKTILHYMGTSTFSEYTVVADISVAKIDPLAPLDKVCLLGCGISTGYGAAVNTAKLEPGSVCAVFGLGGVGLAVIMGCKVAGASRIIGVDINKDKFARAKEFGATECINPQDFSKPIQEVLIEMTDGGVDYSFECIGNVKVMRAALEACHKGWGVSVVVGVAASGEEIATRPFQLVTGRTWKGTAFGGWKSVESVPKLVSEYMSKKIKVDEFVTHNLSFDEINKAFELMHSGKSIRTVVKI
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Function:
- Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione.
- Catalytic Activity:
- An alcohol + NAD(+) = an aldehyde or ketone + NADH.; S-(hydroxymethyl)glutathione + NAD(P)(+) = S-formylglutathione + NAD(P)H.
- Cofactor:
- COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Cross Reference Drug Bank:
- DB00898
- Gene Ontology Go:
- cytosol
extracellular exosome
mitochondrion
alcohol dehydrogenase (NAD) activity
electron carrier activity
fatty acid binding
formaldehyde dehydrogenase activity
S-(hydroxymethyl)glutathione dehydrogenase activity
zinc ion binding
ethanol oxidation
formaldehyde catabolic process
peptidyl-cysteine S-nitrosylation
positive regulation of blood pressure
respiratory system process
response to lipopolysaccharide
response to nitrosative stress
response to redox state
retinoid metabolic process
small molecule metabolic process
xenobiotic metabolic process - Gene Ontology Biological Process:
- ethanol oxidation
formaldehyde catabolic process
peptidyl-cysteine S-nitrosylation
positive regulation of blood pressure
respiratory system process
response to lipopolysaccharide
response to nitrosative stress
response to redox state
retinoid metabolic process
small molecule metabolic process
xenobiotic metabolic process - Gene Ontology Molecular Function:
- alcohol dehydrogenase (NAD) activity
electron carrier activity
fatty acid binding
formaldehyde dehydrogenase activity
S-(hydroxymethyl)glutathione dehydrogenase activity
zinc ion binding - Gene Ontology Cellular Component:
- cytosol
extracellular exosome
mitochondrion - Keywords:
- 3D-structure
Acetylation
Complete proteome
Cytoplasm
Direct protein sequencing
Metal-binding
NAD
Oxidoreductase
Phosphoprotein
Polymorphism
Reference proteome
Zinc