Names & Taxonomy
- Uniprot ID:
- P11362
- Entry Name:
- FGFR1_HUMAN
- Status:
- reviewed
- Protein Names:
- Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr) (CD antigen CD331)
- Gene Names:
- FGFR1 BFGFR CEK FGFBR FLG FLT2 HBGFR
- Gene Names Primary:
- FGFR1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 822
- Sequence:
- MWSWKCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQLRCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Single-pass type I membrane protein. Nucleus. Cytoplasm, cytosol. Cytoplasmic vesicle. Note=After ligand binding, both receptor and ligand are rapidly internalized. Can translocate to the nucleus after internalization, or by translocation from the endoplasmic reticulum or Golgi apparatus to the cytosol, and from there to the nucleus.
Function
- Function:
- Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation.
- Catalytic Activity:
- ATP + a -L-tyrosine = ADP + a -L-tyrosine phosphate.
- Enzyme Regulation:
- ENZYME REGULATION: Present in an inactive conformation in the absence of bound ligand. Ligand binding leads to dimerization and activation by sequential autophosphorylation on tyrosine residues. Inhibited by ARQ 069; this compound maintains the kinase in an inactive conformation and inhibits autophosphorylation. Inhibited by PD173074.
- Active Site:
- ACT_SITE 623 623 Proton acceptor.
- Cross Reference Drug Bank:
- DB09078 DB09079 DB00039 DB08901 DB08896 DB00398
- Gene Ontology Go:
- cytoplasmic, membrane-bounded vesicle
cytosol
extracellular region
integral component of membrane
integral component of plasma membrane
nucleus
plasma membrane
receptor complex
ATP binding
fibroblast growth factor binding
fibroblast growth factor-activated receptor activity
heparin binding
identical protein binding
protein homodimerization activity
protein tyrosine kinase activity
activation of MAPKK activity
angiogenesis
auditory receptor cell development
axon guidance
branching involved in salivary gland morphogenesis
cell maturation
cell migration
chondrocyte differentiation
chordate embryonic development
embryonic limb morphogenesis
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development
in utero embryonic development
innate immune response
inner ear morphogenesis
insulin receptor signaling pathway
lung-associated mesenchyme development
MAPK cascade
mesenchymal cell differentiation
midbrain development
middle ear morphogenesis
motogenic signaling involved in postnatal olfactory bulb interneuron migration
negative regulation of osteoblast differentiation
negative regulation of transcription from RNA polymerase II promoter
neuron migration
neurotrophin TRK receptor signaling pathway
organ induction
outer ear morphogenesis
paraxial mesoderm development
peptidyl-tyrosine phosphorylation
phosphatidylinositol-mediated signaling
positive regulation of cardiac muscle cell proliferation
positive regulation of cell cycle
positive regulation of cell proliferation
positive regulation of endothelial cell chemotaxis to fibroblast growth factor
positive regulation of MAP kinase activity
positive regulation of MAPK cascade
positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
positive regulation of mesenchymal cell proliferation
positive regulation of neuron differentiation
positive regulation of neuron projection development
positive regulation of phosphatidylinositol 3-kinase signaling
positive regulation of phospholipase activity
positive regulation of phospholipase C activity
protein autophosphorylation
protein phosphorylation
Ras protein signal transduction
regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
regulation of cell differentiation
regulation of extrinsic apoptotic signaling pathway in absence of ligand
regulation of lateral mesodermal cell fate specification
regulation of sensory perception of pain
sensory perception of sound
skeletal system development
skeletal system morphogenesis
small GTPase mediated signal transduction
stem cell population maintenance
transcription, DNA-templated
ureteric bud development
vascular endothelial growth factor receptor signaling pathway
ventricular zone neuroblast division - Gene Ontology Biological Process:
- activation of MAPKK activity
angiogenesis
auditory receptor cell development
axon guidance
branching involved in salivary gland morphogenesis
cell maturation
cell migration
chondrocyte differentiation
chordate embryonic development
embryonic limb morphogenesis
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development
innate immune response
inner ear morphogenesis
insulin receptor signaling pathway
in utero embryonic development
lung-associated mesenchyme development
MAPK cascade
mesenchymal cell differentiation
midbrain development
middle ear morphogenesis
motogenic signaling involved in postnatal olfactory bulb interneuron migration
negative regulation of osteoblast differentiation
negative regulation of transcription from RNA polymerase II promoter
neuron migration
neurotrophin TRK receptor signaling pathway
organ induction
outer ear morphogenesis
paraxial mesoderm development
peptidyl-tyrosine phosphorylation
phosphatidylinositol-mediated signaling
positive regulation of cardiac muscle cell proliferation
positive regulation of cell cycle
positive regulation of cell proliferation
positive regulation of endothelial cell chemotaxis to fibroblast growth factor
positive regulation of MAPK cascade
positive regulation of MAP kinase activity
positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
positive regulation of mesenchymal cell proliferation
positive regulation of neuron differentiation
positive regulation of neuron projection development
positive regulation of phosphatidylinositol 3-kinase signaling
positive regulation of phospholipase activity
positive regulation of phospholipase C activity
protein autophosphorylation
protein phosphorylation
Ras protein signal transduction
regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
regulation of cell differentiation
regulation of extrinsic apoptotic signaling pathway in absence of ligand
regulation of lateral mesodermal cell fate specification
regulation of sensory perception of pain
sensory perception of sound
skeletal system development
skeletal system morphogenesis
small GTPase mediated signal transduction
stem cell population maintenance
transcription, DNA-templated
ureteric bud development
vascular endothelial growth factor receptor signaling pathway
ventricular zone neuroblast division - Gene Ontology Molecular Function:
- ATP binding
fibroblast growth factor-activated receptor activity
fibroblast growth factor binding
heparin binding
identical protein binding
protein homodimerization activity
protein tyrosine kinase activity - Gene Ontology Cellular Component:
- cytoplasmic, membrane-bounded vesicle
cytosol
extracellular region
integral component of membrane
integral component of plasma membrane
nucleus
plasma membrane
receptor complex - Keywords:
- 3D-structure
ATP-binding
Alternative splicing
Cell membrane
Chromosomal rearrangement
Complete proteome
Craniosynostosis
Cytoplasm
Cytoplasmic vesicle
Direct protein sequencing
Disease mutation
Disulfide bond
Dwarfism
Glycoprotein
Heparin-binding
Holoprosencephaly
Hypogonadotropic hypogonadism
Immunoglobulin domain
Kallmann syndrome
Kinase
Membrane
Mental retardation
Nucleotide-binding
Nucleus
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Repeat
Signal
Transcription
Transcription regulation
Transferase
Transmembrane
Transmembrane helix
Tyrosine-protein kinase
Ubl conjugation - Interacts With:
- Itself; P23352; P12830; P46108; P35222; P05230; P09038; O88900; P08908; P46934; Q8IVI9; P27986; P19174; P10686
Publication
- PubMed ID:
- 2162671 1697263 2167437 2159626 1722683 1662973 1650441 1846977 1317750 20139426 14702039 16421571 15489334 7520751 8074689 1652059 1847500 1656221 1379697 1379698 7516330 8622701 8663044 9716603 9655399 9949182 10454568 10688839 11353842 12181353 15034873 15117958 16335952 16946300 16597617 16481405 16507368 17389761 17623664 17311277 18480409 19696444 19261810 19224897 19966287 21765395 12141425 15863030 20094046 20117945 8752212 9139660 10830168 11030354 19665973 20133753 21454610 7874169 11173846 12627230 15001591 15625620 15605412 15845591 16470795 16882753 16764984 16757108 16606836 17154279 17344846 19820032 21700882 22927827 23643382 23812909 24888332 25077900 26277103