Names & Taxonomy

Uniprot ID:
P11230
Entry Name:
ACHB_HUMAN
Status:
reviewed
Protein Names:
Acetylcholine receptor subunit beta
Gene Names:
CHRNB1 ACHRB CHRNB
Gene Names Primary:
CHRNB1
Organism:
Homo sapiens (Human)

Structure

Length:
501
Sequence:
MTPGALLMLLGALGAPLAPGVRGSEAEGRLREKLFSGYDSSVRPAREVGDRVRVSVGLILAQLISLNEKDEEMSTKVYLDLEWTDYRLSWDPAEHDGIDSLRITAESVWLPDVVLLNNNDGNFDVALDISVVVSSDGSVRWQPPGIYRSSCSIQVTYFPFDWQNCTMVFSSYSYDSSEVSLQTGLGPDGQGHQEIHIHEGTFIENGQWEIIHKPSRLIQPPGDPRGGREGQRQEVIFYLIIRRKPLFYLVNVIAPCILITLLAIFVFYLPPDAGEKMGLSIFALLTLTVFLLLLADKVPETSLSVPIIIKYLMFTMVLVTFSVILSVVVLNLHHRSPHTHQMPLWVRQIFIHKLPLYLRLKRPKPERDLMPEPPHCSSPGSGWGRGTDEYFIRKPPSDFLFPKPNRFQPELSAPDLRRFIDGPNRAVALLPELREVVSSISYIARQLQEQEDHDALKEDWQFVAMVVDRLFLWTFIIFTSVGTLVIFLDATYHLPPPDPFP
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Function

Function:
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Cross Reference Drug Bank:
DB00674
Gene Ontology Go:
acetylcholine-gated channel complex
cell junction
integral component of plasma membrane
postsynaptic membrane
synapse
acetylcholine binding
acetylcholine-activated cation-selective channel activity
channel activity
ligand-gated ion channel activity
behavioral response to nicotine
cation transmembrane transport
cation transport
chemical synaptic transmission, postsynaptic
muscle contraction
muscle fiber development
neurological system process
neuromuscular synaptic transmission
postsynaptic membrane organization
regulation of membrane potential
signal transduction
skeletal muscle contraction
synaptic transmission, cholinergic
Gene Ontology Biological Process:
behavioral response to nicotine
cation transmembrane transport
cation transport
chemical synaptic transmission, postsynaptic
muscle contraction
muscle fiber development
neurological system process
neuromuscular synaptic transmission
postsynaptic membrane organization
regulation of membrane potential
signal transduction
skeletal muscle contraction
synaptic transmission, cholinergic
Gene Ontology Molecular Function:
acetylcholine-activated cation-selective channel activity
acetylcholine binding
channel activity
ligand-gated ion channel activity
Gene Ontology Cellular Component:
acetylcholine-gated channel complex
cell junction
integral component of plasma membrane
postsynaptic membrane
synapse
Keywords:
Alternative splicing
Cell junction
Cell membrane
Complete proteome
Congenital myasthenic syndrome
Disease mutation
Disulfide bond
Glycoprotein
Ion channel
Ion transport
Ligand-gated ion channel
Membrane
Phosphoprotein
Polymorphism
Postsynaptic cell membrane
Receptor
Reference proteome
Signal
Synapse
Transmembrane
Transmembrane helix
Transport

Publication

PubMed ID:
2740233 14702039 16625196 15489334 8651643 8872460 10562302