Names & Taxonomy
- Uniprot ID:
- P11229
- Entry Name:
- ACM1_HUMAN
- Status:
- reviewed
- Protein Names:
- Muscarinic acetylcholine receptor M1
- Gene Names:
- CHRM1
- Gene Names Primary:
- CHRM1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 460
- Sequence:
- MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
Function
- Function:
- The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
- Cross Reference Drug Bank:
- DB08897 DB00321 DB00543 DB00517 DB01238 DB00572 DB00245 DB00810 DB00835 DB00354 DB00411 DB00185 DB00477 DB01239 DB00568 DB00215 DB00771 DB00363 DB00907 DB00785 DB00979 DB00942 DB00434 DB00496 DB01151 DB00804 DB01231 DB00280 DB01142 DB00366 DB01175 DB00392 DB06702 DB01148 DB00875 DB00986 DB00725 DB00424 DB00458 DB00332 DB01221 DB00408 DB00934 DB04843 DB00940 DB01403 DB00462 DB00340 DB01233 DB00805 DB01618 DB00622 DB00540 DB00334 DB01062 DB00383 DB00219 DB00715 DB00454 DB01085 DB00670 DB00387 DB00420 DB01069 DB00782 DB00777 DB01224 DB00747 DB01591 DB00202 DB01409 DB01036 DB00508 DB00376 DB00726 DB00809 DB00209 DB09076 DB00246
- Gene Ontology Go:
- asymmetric synapse
axon terminus
cell junction
dendrite
integral component of plasma membrane
membrane
plasma membrane
postsynaptic density
postsynaptic membrane
synapse
drug binding
G-protein coupled acetylcholine receptor activity
phosphatidylinositol phospholipase C activity
adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway
cell proliferation
cellular protein modification process
cognition
G-protein coupled acetylcholine receptor signaling pathway
G-protein coupled receptor signaling pathway
nervous system development
neuromuscular synaptic transmission
phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway
positive regulation of cell proliferation
positive regulation of intracellular protein transport
positive regulation of ion transport
protein kinase C-activating G-protein coupled receptor signaling pathway
regulation of locomotion
regulation of vascular smooth muscle contraction
saliva secretion
signal transduction
synaptic transmission, cholinergic - Gene Ontology Biological Process:
- adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway
cell proliferation
cellular protein modification process
cognition
G-protein coupled acetylcholine receptor signaling pathway
G-protein coupled receptor signaling pathway
nervous system development
neuromuscular synaptic transmission
phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway
positive regulation of cell proliferation
positive regulation of intracellular protein transport
positive regulation of ion transport
protein kinase C-activating G-protein coupled receptor signaling pathway
regulation of locomotion
regulation of vascular smooth muscle contraction
saliva secretion
signal transduction
synaptic transmission, cholinergic - Gene Ontology Molecular Function:
- drug binding
G-protein coupled acetylcholine receptor activity
phosphatidylinositol phospholipase C activity - Gene Ontology Cellular Component:
- asymmetric synapse
axon terminus
cell junction
dendrite
integral component of plasma membrane
membrane
plasma membrane
postsynaptic density
postsynaptic membrane
synapse - Keywords:
- 3D-structure
Alternative splicing
Cell junction
Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Membrane
Phosphoprotein
Postsynaptic cell membrane
Receptor
Reference proteome
Synapse
Transducer
Transmembrane
Transmembrane helix