Names & Taxonomy

Uniprot ID:
P11226
Entry Name:
MBL2_HUMAN
Status:
reviewed
Protein Names:
Mannose-binding protein C (MBP-C) (Collectin-1) (MBP1) (Mannan-binding protein) (Mannose-binding lectin)
Gene Names:
MBL2 COLEC1 MBL
Gene Names Primary:
MBL2
Organism:
Homo sapiens (Human)

Structure

Length:
248
Sequence:
MSLFPSLPLLLLSMVAASYSETVTCEDAQKTCPAVIACSSPGINGFPGKDGRDGTKGEKGEPGQGLRGLQGPPGKLGPPGNPGPSGSPGPKGQKGDPGKSPDGDSSLAASERKALQTEMARIKKWLTFSLGKQVGNKFFLTNGEIMTFEKVKALCVKFQASVATPRNAAENGAIQNLIKEEAFLGITDEKTEGQFVDLTGNRLTYTNWNEGEPNNAGSDEDCVLLLKNGQWNDVPCSTSHLAVCEFPI
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Secreted

Function

Function:
Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA.
Gene Ontology Go:
cell surface
collagen trimer
extracellular region
extracellular space
calcium ion binding
calcium-dependent protein binding
mannose binding
receptor binding
acute-phase response
complement activation
complement activation, classical pathway
complement activation, lectin pathway
defense response to bacterium
defense response to Gram-positive bacterium
innate immune response
killing by host of symbiont cells
negative regulation of growth of symbiont in host
negative regulation of viral process
opsonization
positive regulation of phagocytosis
response to oxidative stress
Gene Ontology Biological Process:
acute-phase response
complement activation
complement activation, classical pathway
complement activation, lectin pathway
defense response to bacterium
defense response to Gram-positive bacterium
innate immune response
killing by host of symbiont cells
negative regulation of growth of symbiont in host
negative regulation of viral process
opsonization
positive regulation of phagocytosis
response to oxidative stress
Gene Ontology Molecular Function:
calcium-dependent protein binding
calcium ion binding
mannose binding
receptor binding
Gene Ontology Cellular Component:
cell surface
collagen trimer
extracellular region
extracellular space
Keywords:
3D-structure
Calcium
Coiled coil
Collagen
Complement activation lectin pathway
Complement pathway
Complete proteome
Direct protein sequencing
Disulfide bond
Hydroxylation
Immunity
Innate immunity
Lectin
Mannose-binding
Polymorphism
Reference proteome
Repeat
Secreted
Signal
Interacts With:
Q07954

Publication

PubMed ID:
2450948 2477486 2590164 9743385 15489334 12175909 7982896 9087411 14515269 15145932 16116208 18006063 24275569 7634089 1675710 1304173 1303250 10447262 15994813 21695215