Names & Taxonomy

Uniprot ID:
P11177
Entry Name:
ODPB_HUMAN
Status:
reviewed
Protein Names:
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial (PDHE1-B) (EC 1.2.4.1)
Gene Names:
PDHB PHE1B
Gene Names Primary:
PDHB
Organism:
Homo sapiens (Human)

Structure

Length:
359
Sequence:
MAAVSGLVRRPLREVSGLLKRRFHWTAPAALQVTVRDAINQGMDEELERDEKVFLLGEEVAQYDGAYKVSRGLWKKYGDKRIIDTPISEMGFAGIAVGAAMAGLRPICEFMTFNFSMQAIDQVINSAAKTYYMSGGLQPVPIVFRGPNGASAGVAAQHSQCFAAWYGHCPGLKVVSPWNSEDAKGLIKSAIRDNNPVVVLENELMYGVPFEFPPEAQSKDFLIPIGKAKIERQGTHITVVSHSRPVGHCLEAAAVLSKEGVECEVINMRTIRPMDMETIEASVMKTNHLVTVEGGWPQFGVGAEICARIMEGPAFNFLDAPAVRVTGADVPMPYAKILEDNSIPQVKDIIFAIKKTLNI
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Mitochondrion matrix.

Function

Function:
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.
Catalytic Activity:
Pyruvate + lipoyllysine = S-acetyldihydrolipoyllysine + CO(2).
Cofactor:
COFACTOR: Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
Cross Reference Drug Bank:
DB00119
Gene Ontology Go:
extracellular exosome
mitochondrial matrix
mitochondrion
nucleoplasm
nucleus
pyruvate dehydrogenase complex
pyruvate dehydrogenase (acetyl-transferring) activity
pyruvate dehydrogenase activity
acetyl-CoA biosynthetic process from pyruvate
cellular metabolic process
cellular nitrogen compound metabolic process
glucose metabolic process
glyoxylate metabolic process
mitochondrial acetyl-CoA biosynthetic process from pyruvate
pyruvate metabolic process
regulation of acetyl-CoA biosynthetic process from pyruvate
small molecule metabolic process
tricarboxylic acid cycle
Gene Ontology Biological Process:
acetyl-CoA biosynthetic process from pyruvate
cellular metabolic process
cellular nitrogen compound metabolic process
glucose metabolic process
glyoxylate metabolic process
mitochondrial acetyl-CoA biosynthetic process from pyruvate
pyruvate metabolic process
regulation of acetyl-CoA biosynthetic process from pyruvate
small molecule metabolic process
tricarboxylic acid cycle
Gene Ontology Molecular Function:
pyruvate dehydrogenase (acetyl-transferring) activity
pyruvate dehydrogenase activity
Gene Ontology Cellular Component:
extracellular exosome
mitochondrial matrix
mitochondrion
nucleoplasm
nucleus
pyruvate dehydrogenase complex
Keywords:
3D-structure
Acetylation
Alternative splicing
Carbohydrate metabolism
Complete proteome
Direct protein sequencing
Disease mutation
Glucose metabolism
Mitochondrion
Oxidoreductase
Phosphoprotein
Polymorphism
Pyruvate
Reference proteome
Thiamine pyrophosphate
Transit peptide
Tricarboxylic acid cycle
Interacts With:
P10515

Publication

PubMed ID:
2323578 1702713 2376596 2377599 3422424 11230166 14702039 16641997 15489334 2829898 7895732 2295468 14638692 21269460 24275569 25944712 12651851 17474719 19081061 15138885