Names & Taxonomy
- Uniprot ID:
- P11166
- Entry Name:
- GTR1_HUMAN
- Status:
- reviewed
- Protein Names:
- Solute carrier family 2, facilitated glucose transporter member 1 (Glucose transporter type 1, erythrocyte/brain) (GLUT-1) (HepG2 glucose transporter)
- Gene Names:
- SLC2A1 GLUT1
- Gene Names Primary:
- SLC2A1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 492
- Sequence:
- MEPSSKKLTGRLMLAVGGAVLGSLQFGYNTGVINAPQKVIEEFYNQTWVHRYGESILPTTLTTLWSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLMMNLLAFVSAVLMGFSKLGKSFEMLILGRFIIGVYCGLTTGFVPMYVGEVSPTALRGALGTLHQLGIVVGILIAQVFGLDSIMGNKDLWPLLLSIIFIPALLQCIVLPFCPESPRFLLINRNEENRAKSVLKKLRGTADVTHDLQEMKEESRQMMREKKVTILELFRSPAYRQPILIAVVLQLSQQLSGINAVFYYSTSIFEKAGVQQPVYATIGSGIVNTAFTVVSLFVVERAGRRTLHLIGLAGMAGCAILMTIALALLEQLPWMSYLSIVAIFGFVAFFEVGPGPIPWFIVAELFSQGPRPAAIAVAGFSNWTSNFIVGMCFQYVEQLCGPYVFIIFTVLLVLFFIFTYFKVPETKGRTFDEIASGFRQGGASQSDKTPEELFHPLGADSQV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein. Melanosome. Note=Localizes primarily at the cell surface. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Function
- Function:
- Facilitative glucose transporter. This isoform may be responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses.
- Cross Reference Drug Bank:
- DB00292
- Gene Ontology Go:
- apical plasma membrane
basolateral plasma membrane
blood microparticle
caveola
cell-cell junction
cortical actin cytoskeleton
cytosol
extracellular exosome
female pronucleus
Golgi membrane
integral component of plasma membrane
melanosome
membrane
midbody
plasma membrane
D-glucose transmembrane transporter activity
dehydroascorbic acid transporter activity
glucose transmembrane transporter activity
identical protein binding
protein self-association
xenobiotic transporter activity
carbohydrate metabolic process
cellular response to glucose starvation
energy reserve metabolic process
glucose transport
hexose transport
L-ascorbic acid metabolic process
lactose biosynthetic process
protein complex assembly
regulation of insulin secretion
response to osmotic stress
small molecule metabolic process
transmembrane transport
vitamin metabolic process
water-soluble vitamin metabolic process - Gene Ontology Biological Process:
- carbohydrate metabolic process
cellular response to glucose starvation
energy reserve metabolic process
glucose transport
hexose transport
lactose biosynthetic process
L-ascorbic acid metabolic process
protein complex assembly
regulation of insulin secretion
response to osmotic stress
small molecule metabolic process
transmembrane transport
vitamin metabolic process
water-soluble vitamin metabolic process - Gene Ontology Molecular Function:
- dehydroascorbic acid transporter activity
D-glucose transmembrane transporter activity
glucose transmembrane transporter activity
identical protein binding
protein self-association
xenobiotic transporter activity - Gene Ontology Cellular Component:
- apical plasma membrane
basolateral plasma membrane
blood microparticle
caveola
cell-cell junction
cortical actin cytoskeleton
cytosol
extracellular exosome
female pronucleus
Golgi membrane
integral component of plasma membrane
melanosome
membrane
midbody
plasma membrane - Keywords:
- 3D-structure
Acetylation
Cell membrane
Complete proteome
Direct protein sequencing
Disease mutation
Dystonia
Epilepsy
Glycoprotein
Membrane
Phosphoprotein
Reference proteome
Sugar transport
Transmembrane
Transmembrane helix
Transport - Interacts With:
- Itself
Publication
- PubMed ID:
- 3839598 14702039 15489334 2834252 17081065 18245775 18347014 18691976 19449892 19349973 20068231 21269460 21406692 22814378 23219802 23563491 24275569 24847886 10227690 10980529 11603379 11136715 12325075 14605501 15622525 18451999 19798636 19901175 19630075 20221955 20129935 21204808 20621801 20574033 20830593 21832227 22282645