Names & Taxonomy
- Uniprot ID:
- P11086
- Entry Name:
- PNMT_HUMAN
- Status:
- reviewed
- Protein Names:
- Phenylethanolamine N-methyltransferase (PNMTase) (EC 2.1.1.28) (Noradrenaline N-methyltransferase)
- Gene Names:
- PNMT PENT
- Gene Names Primary:
- PNMT
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 282
- Sequence:
- MSGADRSPNAGAAPDSAPGQAAVASAYQRFEPRAYLRNNYAPPRGDLCNPNGVGPWKLRCLAQTFATGEVSGRTLIDIGSGPTVYQLLSACSHFEDITMTDFLEVNRQELGRWLQEEPGAFNWSMYSQHACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLGAGSPAPLPADALVSAFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLTVVPVSEEEVREALVRSGYKVRDLRTYIMPAHLQTGVDDVKGVFFAWAQKVGL
- Proteomes:
- UP000005640
Function
- Function:
- Converts noradrenaline to adrenaline.
- Pathway:
- Catecholamine biosynthesis; (R)-adrenaline biosynthesis; (R)-adrenaline from (R)-noradrenaline: step 1/1.
- Catalytic Activity:
- S-adenosyl-L-methionine + phenylethanolamine = S-adenosyl-L-homocysteine + N-methylphenylethanolamine.
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=99 uM for phenylethanolamine
- Gene Ontology Go:
- cytosol
phenylethanolamine N-methyltransferase activity
catecholamine biosynthetic process
cellular nitrogen compound metabolic process
epinephrine biosynthetic process
small molecule metabolic process - Gene Ontology Biological Process:
- catecholamine biosynthetic process
cellular nitrogen compound metabolic process
epinephrine biosynthetic process
small molecule metabolic process - Gene Ontology Molecular Function:
- phenylethanolamine N-methyltransferase activity
- Gene Ontology Cellular Component:
- cytosol
- Keywords:
- 3D-structure
Catecholamine biosynthesis
Complete proteome
Methyltransferase
Polymorphism
Reference proteome
S-adenosyl-L-methionine
Transferase