Names & Taxonomy
- Uniprot ID:
- P10915
- Entry Name:
- HPLN1_HUMAN
- Status:
- reviewed
- Protein Names:
- Hyaluronan and proteoglycan link protein 1 (Cartilage-linking protein 1) (Cartilage-link protein) (Proteoglycan link protein)
- Gene Names:
- HAPLN1 CRTL1
- Gene Names Primary:
- HAPLN1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 354
- Sequence:
- MKSLLLLVLISICWADHLSDNYTLDHDRAIHIQAENGPHLLVEAEQAKVFSHRGGNVTLPCKFYRDPTAFGSGIHKIRIKWTKLTSDYLKEVDVFVSMGYHKKTYGGYQGRVFLKGGSDSDASLVITDLTLEDYGRYKCEVIEGLEDDTVVVALDLQGVVFPYFPRLGRYNLNFHEAQQACLDQDAVIASFDQLYDAWRGGLDWCNAGWLSDGSVQYPITKPREPCGGQNTVPGVRNYGFWDKDKSRYDVFCFTSNFNGRFYYLIHPTKLTYDEAVQACLNDGAQIAKVGQIFAAWKILGYDRCDAGWLADGSVRYPISRPRRRCSPTEAAVRFVGFPDKKHKLYGVYCFRAYN
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted, extracellular space, extracellular matrix.
Function
- Function:
- Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix.
- Cross Reference Drug Bank:
- DB08818
- Gene Ontology Go:
- extracellular region
proteinaceous extracellular matrix
hyaluronic acid binding
cell adhesion
central nervous system development
extracellular matrix organization
mitophagy in response to mitochondrial depolarization
skeletal system development - Gene Ontology Biological Process:
- cell adhesion
central nervous system development
extracellular matrix organization
mitophagy in response to mitochondrial depolarization
skeletal system development - Gene Ontology Molecular Function:
- hyaluronic acid binding
- Gene Ontology Cellular Component:
- extracellular region
proteinaceous extracellular matrix - Keywords:
- Complete proteome
Disulfide bond
Extracellular matrix
Glycoprotein
Hyaluronic acid
Immunoglobulin domain
Polymorphism
Reference proteome
Repeat
Secreted