Names & Taxonomy
- Uniprot ID:
- P10827
- Entry Name:
- THA_HUMAN
- Status:
- reviewed
- Protein Names:
- Thyroid hormone receptor alpha (Nuclear receptor subfamily 1 group A member 1) (V-erbA-related protein 7) (EAR-7) (c-erbA-1) (c-erbA-alpha)
- Gene Names:
- THRA EAR7 ERBA1 NR1A1 THRA1 THRA2
- Gene Names Primary:
- THRA
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 490
- Sequence:
- MEQKPSKVECGSDPEENSARSPDGKRKRKNGQCSLKTSMSGYIPSYLDKDEQCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNIPHFWPKLLMKEREVQSSILYKGAAAEGRPGGSLGVHPEGQQLLGMHVVQGPQVRQLEQQLGEAGSLQGPVLQHQSPKSPQQRLLELLHRSGILHARAVCGEDDSSEADSPSSSEEEPEVCEDLAGNAASP
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus.
Function
- Function:
- Isoform Alpha-1: Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.
- Cross Reference Drug Bank:
- DB00509 DB00451 DB00279 DB01583
- Gene Ontology Go:
- cytosol
mitochondrion
nucleoplasm
nucleus
chromatin DNA binding
intronic transcription regulatory region DNA binding
protein domain specific binding
steroid hormone receptor activity
steroid receptor RNA activator RNA binding
TBP-class protein binding
thyroid hormone binding
thyroid hormone receptor activity
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
transcription factor activity, sequence-specific DNA binding
transcription factor binding
transcription regulatory region DNA binding
transcription regulatory region sequence-specific DNA binding
zinc ion binding
adrenal gland development
brain development
cartilage condensation
cytoplasmic sequestering of transcription factor
digestive tract development
embryonic organ development
erythrocyte differentiation
female courtship behavior
gene expression
hormone-mediated signaling pathway
intracellular receptor signaling pathway
kidney development
learning or memory
liver development
negative regulation of DNA-templated transcription, initiation
negative regulation of RNA polymerase II transcriptional preinitiation complex assembly
negative regulation of sequence-specific DNA binding transcription factor activity
negative regulation of transcription, DNA-templated
ossification
positive regulation of female receptivity
positive regulation of myotube differentiation
positive regulation of transcription from RNA polymerase II promoter
regulation of heart contraction
regulation of lipid catabolic process
regulation of myeloid cell apoptotic process
regulation of thyroid hormone mediated signaling pathway
regulation of transcription from RNA polymerase II promoter
response to cold
response to drug
response to nutrient levels
thyroid gland development
transcription from RNA polymerase II promoter
transcription initiation from RNA polymerase II promoter
Type I pneumocyte differentiation - Gene Ontology Biological Process:
- adrenal gland development
brain development
cartilage condensation
cytoplasmic sequestering of transcription factor
digestive tract development
embryonic organ development
erythrocyte differentiation
female courtship behavior
gene expression
hormone-mediated signaling pathway
intracellular receptor signaling pathway
kidney development
learning or memory
liver development
negative regulation of DNA-templated transcription, initiation
negative regulation of RNA polymerase II transcriptional preinitiation complex assembly
negative regulation of sequence-specific DNA binding transcription factor activity
negative regulation of transcription, DNA-templated
ossification
positive regulation of female receptivity
positive regulation of myotube differentiation
positive regulation of transcription from RNA polymerase II promoter
regulation of heart contraction
regulation of lipid catabolic process
regulation of myeloid cell apoptotic process
regulation of thyroid hormone mediated signaling pathway
regulation of transcription from RNA polymerase II promoter
response to cold
response to drug
response to nutrient levels
thyroid gland development
transcription from RNA polymerase II promoter
transcription initiation from RNA polymerase II promoter
Type I pneumocyte differentiation - Gene Ontology Molecular Function:
- chromatin DNA binding
intronic transcription regulatory region DNA binding
protein domain specific binding
steroid hormone receptor activity
steroid receptor RNA activator RNA binding
TBP-class protein binding
thyroid hormone binding
thyroid hormone receptor activity
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
transcription factor activity, sequence-specific DNA binding
transcription factor binding
transcription regulatory region DNA binding
transcription regulatory region sequence-specific DNA binding
zinc ion binding - Gene Ontology Cellular Component:
- cytosol
mitochondrion
nucleoplasm
nucleus - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Congenital hypothyroidism
DNA-binding
Disease mutation
Isopeptide bond
Metal-binding
Nucleus
Polymorphism
Receptor
Reference proteome
Transcription
Transcription regulation
Ubl conjugation
Zinc
Zinc-finger - Interacts With:
- Q9Y2J4-4; Q96JM7; Q15648; Q9JLI4