Names & Taxonomy

Uniprot ID:
P10768
Entry Name:
ESTD_HUMAN
Status:
reviewed
Protein Names:
S-formylglutathione hydrolase (FGH) (EC 3.1.2.12) (Esterase D) (Methylumbelliferyl-acetate deacetylase) (EC 3.1.1.56)
Gene Names:
ESD
Gene Names Primary:
ESD
Organism:
Homo sapiens (Human)

Structure

Length:
282
Sequence:
MALKQISSNKCFGGLQKVFEHDSVELNCKMKFAVYLPPKAETGKCPALYWLSGLTCTEQNFISKSGYHQSASEHGLVVIAPDTSPRGCNIKGEDESWDFGTGAGFYVDATEDPWKTNYRMYSYVTEELPQLINANFPVDPQRMSIFGHSMGGHGALICALKNPGKYKSVSAFAPICNPVLCPWGKKAFSGYLGTDQSKWKAYDATHLVKSYPGSQLDILIDQGKDDQFLLDGQLLPDNFIAACTEKKIPVVFRLQEGYDHSYYFIATFITDHIRHHAKYLNA
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm. Cytoplasmic vesicle.

Function

Function:
Serine hydrolase involved in the detoxification of formaldehyde.
Catalytic Activity:
S-formylglutathione + H(2)O = glutathione + formate.
Active Site:
ACT_SITE 149 149 Charge relay system.
Cross Reference Drug Bank:
DB00143
Gene Ontology Go:
cytoplasmic, membrane-bounded vesicle
endoplasmic reticulum lumen
extracellular exosome
carboxylic ester hydrolase activity
hydrolase activity, acting on ester bonds
methylumbelliferyl-acetate deacetylase activity
S-formylglutathione hydrolase activity
formaldehyde catabolic process
glutathione derivative biosynthetic process
small molecule metabolic process
xenobiotic metabolic process
Gene Ontology Biological Process:
formaldehyde catabolic process
glutathione derivative biosynthetic process
small molecule metabolic process
xenobiotic metabolic process
Gene Ontology Molecular Function:
carboxylic ester hydrolase activity
hydrolase activity, acting on ester bonds
methylumbelliferyl-acetate deacetylase activity
S-formylglutathione hydrolase activity
Gene Ontology Cellular Component:
cytoplasmic, membrane-bounded vesicle
endoplasmic reticulum lumen
extracellular exosome
Keywords:
3D-structure
Acetylation
Complete proteome
Cytoplasm
Cytoplasmic vesicle
Direct protein sequencing
Hydrolase
Polymorphism
Reference proteome
Serine esterase
Interacts With:
A1L4K1

Publication

PubMed ID:
3462698 3164702 10931946 15057823 15489334 3462714 4768551 3770744 19608861 21269460 24275569 25944712 19126594 7907313 12721789