Names & Taxonomy
- Uniprot ID:
- P10515
- Entry Name:
- ODP2_HUMAN
- Status:
- reviewed
- Protein Names:
- Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial (EC 2.3.1.12) (70 kDa mitochondrial autoantigen of primary biliary cirrhosis) (PBC) (Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex) (M2 antigen complex 70 kDa subunit) (Pyruvate dehydrogenase complex component E2) (PDC-E2) (PDCE2)
- Gene Names:
- DLAT DLTA
- Gene Names Primary:
- DLAT
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 647
- Sequence:
- MWRVCARRAQNVAPWAGLEARWTALQEVPGTPRVTSRSGPAPARRNSVTTGYGGVRALCGWTPSSGATPRNRLLLQLLGSPGRRYYSLPPHQKVPLPSLSPTMQAGTIARWEKKEGDKINEGDLIAEVETDKATVGFESLEECYMAKILVAEGTRDVPIGAIICITVGKPEDIEAFKNYTLDSSAAPTPQAAPAPTPAATASPPTPSAQAPGSSYPPHMQVLLPALSPTMTMGTVQRWEKKVGEKLSEGDLLAEIETDKATIGFEVQEEGYLAKILVPEGTRDVPLGTPLCIIVEKEADISAFADYRPTEVTDLKPQVPPPTPPPVAAVPPTPQPLAPTPSAPCPATPAGPKGRVFVSPLAKKLAVEKGIDLTQVKGTGPDGRITKKDIDSFVPSKVAPAPAAVVPPTGPGMAPVPTGVFTDIPISNIRRVIAQRLMQSKQTIPHYYLSIDVNMGEVLLVRKELNKILEGRSKISVNDFIIKASALACLKVPEANSSWMDTVIRQNHVVDVSVAVSTPAGLITPIVFNAHIKGVETIANDVVSLATKAREGKLQPHEFQGGTFTISNLGMFGIKNFSAIINPPQACILAIGASEDKLVPADNEKGFDVASMMSVTLSCDHRVVDGAVGAQWLAEFRKYLEKPITMLL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion matrix.
Function
- Function:
- The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.
- Catalytic Activity:
- Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine.
- Cofactor:
- COFACTOR: Name=(R)-lipoate; Xref=ChEBI:CHEBI:83088; ; Note=Binds 2 lipoyl cofactors covalently.;
- Active Site:
- ACT_SITE 620 620
- Gene Ontology Go:
- mitochondrial matrix
mitochondrial pyruvate dehydrogenase complex
mitochondrion
myelin sheath
pyruvate dehydrogenase complex
dihydrolipoyllysine-residue acetyltransferase activity
acetyl-CoA biosynthetic process from pyruvate
cellular metabolic process
cellular nitrogen compound metabolic process
glucose metabolic process
glyoxylate metabolic process
pyruvate metabolic process
regulation of acetyl-CoA biosynthetic process from pyruvate
sleep
small molecule metabolic process
tricarboxylic acid cycle - Gene Ontology Biological Process:
- acetyl-CoA biosynthetic process from pyruvate
cellular metabolic process
cellular nitrogen compound metabolic process
glucose metabolic process
glyoxylate metabolic process
pyruvate metabolic process
regulation of acetyl-CoA biosynthetic process from pyruvate
sleep
small molecule metabolic process
tricarboxylic acid cycle - Gene Ontology Molecular Function:
- dihydrolipoyllysine-residue acetyltransferase activity
- Gene Ontology Cellular Component:
- mitochondrial matrix
mitochondrial pyruvate dehydrogenase complex
mitochondrion
myelin sheath
pyruvate dehydrogenase complex - Keywords:
- 3D-structure
Acetylation
Acyltransferase
Carbohydrate metabolism
Complete proteome
Glucose metabolism
Lipoyl
Mitochondrion
Polymorphism
Reference proteome
Repeat
Transferase
Transit peptide
Tricarboxylic acid cycle - Interacts With:
- P11177; Q9Y6E7