Names & Taxonomy
- Uniprot ID:
- P10398
- Entry Name:
- ARAF_HUMAN
- Status:
- reviewed
- Protein Names:
- Serine/threonine-protein kinase A-Raf (EC 2.7.11.1) (Proto-oncogene A-Raf) (Proto-oncogene A-Raf-1) (Proto-oncogene Pks)
- Gene Names:
- ARAF ARAF1 PKS PKS2
- Gene Names Primary:
- ARAF
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 606
- Sequence:
- MEPPRGPPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCVVYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLFHGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRQQFYHSVQDLSGGSRQHEAPSNRPLNELLTPQGPSPRTQHCDPEHFPFPAPANAPLQRIRSTSTPNVHMVSTTAPMDSNLIQLTGQSFSTDAAGSRGGSDGTPRGSPSPASVSSGRKSPHSKSPAEQRERKSLADDKKKVKNLGYRDSGYYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP
- Proteomes:
- UP000005640
Function
- Function:
- Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade.
- Catalytic Activity:
- ATP + a protein = ADP + a phosphoprotein.
- Cofactor:
- COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Active Site:
- ACT_SITE 429 429 Proton acceptor.
- Cross Reference Drug Bank:
- DB00171
- Gene Ontology Go:
- cytosol
ATP binding
metal ion binding
protein kinase activity
protein serine/threonine kinase activity
receptor signaling protein activity
activation of MAPKK activity
axon guidance
cellular protein modification process
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
innate immune response
insulin receptor signaling pathway
MAPK cascade
negative regulation of apoptotic process
neurotrophin TRK receptor signaling pathway
positive regulation of peptidyl-serine phosphorylation
Ras protein signal transduction
regulation of proteasomal ubiquitin-dependent protein catabolic process
regulation of TOR signaling
small GTPase mediated signal transduction
vascular endothelial growth factor receptor signaling pathway - Gene Ontology Biological Process:
- activation of MAPKK activity
axon guidance
cellular protein modification process
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
innate immune response
insulin receptor signaling pathway
MAPK cascade
negative regulation of apoptotic process
neurotrophin TRK receptor signaling pathway
positive regulation of peptidyl-serine phosphorylation
Ras protein signal transduction
regulation of proteasomal ubiquitin-dependent protein catabolic process
regulation of TOR signaling
small GTPase mediated signal transduction
vascular endothelial growth factor receptor signaling pathway - Gene Ontology Molecular Function:
- ATP binding
metal ion binding
protein kinase activity
protein serine/threonine kinase activity
receptor signaling protein activity - Gene Ontology Cellular Component:
- cytosol
- Keywords:
- 3D-structure
ATP-binding
Alternative splicing
Complete proteome
Kinase
Metal-binding
Nucleotide-binding
Phosphoprotein
Polymorphism
Proto-oncogene
Reference proteome
Serine/threonine-protein kinase
Transferase
Zinc
Zinc-finger - Interacts With:
- P00966; P15056; Q9UNS2; P31327; Q12805; P08238; O43187; Q92985; P36507; Q8IXH7; O95848; Q96KB5; P14618; O94906; P53611; P62070; P31947; O43615; Q3ZCQ8; P58753; P62258; P63104