Names & Taxonomy
- Uniprot ID:
- P10114
- Entry Name:
- RAP2A_HUMAN
- Status:
- reviewed
- Protein Names:
- Ras-related protein Rap-2a (RbBP-30)
- Gene Names:
- RAP2A
- Gene Names Primary:
- RAP2A
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 183
- Sequence:
- MREYKVVVLGSGGVGKSALTVQFVTGTFIEKYDPTIEDFYRKEIEVDSSPSVLEILDTAGTEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIIRVKRYEKVPVILVGNKVDLESEREVSSSEGRALAEEWGCPFMETSAKSKTMVDELFAEIVRQMNYAAQPDKDDPCCSACNIQ
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Recycling endosome membrane; Lipid-anchor; Cytoplasmic side. Midbody. Note=May also localize to the Golgi (PubMed:7962206) and the gelatinase-containing granules of neutrophils (PubMed:8391995). Colocalizes with RASGEF1B to midbody at telophase (PubMed:23894443).
Function
- Function:
- Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it is part of several signaling cascades and may regulate cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading.
- Enzyme Regulation:
- ENZYME REGULATION: Activated by the guanine nucleotide-exchange factors RAPGEF3 and RAPGEF4 in a cAMP-dependent manner. Nucleotide exchange is also specifically stimulated by RAPGEF5, RASGEF1A and RASGEF1B.
- Gene Ontology Go:
- cytosol
extracellular exosome
midbody
plasma membrane
recycling endosome
recycling endosome membrane
GTP binding
GTPase activity
actin cytoskeleton reorganization
cellular protein localization
cellular response to drug
establishment of protein localization
microvillus assembly
negative regulation of cell migration
positive regulation of protein autophosphorylation
positive regulation of protein phosphorylation
protein localization to plasma membrane
Rap protein signal transduction
regulation of dendrite morphogenesis
regulation of JNK cascade - Gene Ontology Biological Process:
- actin cytoskeleton reorganization
cellular protein localization
cellular response to drug
establishment of protein localization
microvillus assembly
negative regulation of cell migration
positive regulation of protein autophosphorylation
positive regulation of protein phosphorylation
protein localization to plasma membrane
Rap protein signal transduction
regulation of dendrite morphogenesis
regulation of JNK cascade - Gene Ontology Molecular Function:
- GTPase activity
GTP binding - Gene Ontology Cellular Component:
- cytosol
extracellular exosome
midbody
plasma membrane
recycling endosome
recycling endosome membrane - Keywords:
- 3D-structure
Complete proteome
Endosome
GTP-binding
Lipoprotein
Membrane
Methylation
Nucleotide-binding
Palmitate
Prenylation
Reference proteome
Ubl conjugation