Names & Taxonomy
- Uniprot ID:
- P09923
- Entry Name:
- PPBI_HUMAN
- Status:
- reviewed
- Protein Names:
- Intestinal-type alkaline phosphatase (IAP) (Intestinal alkaline phosphatase) (EC 3.1.3.1)
- Gene Names:
- ALPI
- Gene Names Primary:
- ALPI
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 528
- Sequence:
- MQGPWVLLLLGLRLQLSLGVIPAEEENPAFWNRQAAEALDAAKKLQPIQKVAKNLILFLGDGLGVPTVTATRILKGQKNGKLGPETPLAMDRFPYLALSKTYNVDRQVPDSAATATAYLCGVKANFQTIGLSAAARFNQCNTTRGNEVISVMNRAKQAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADMPASARQEGCQDIATQLISNMDIDVILGGGRKYMFPMGTPDPEYPADASQNGIRLDGKNLVQEWLAKHQGAWYVWNRTELMQASLDQSVTHLMGLFEPGDTKYEIHRDPTLDPSLMEMTEAALRLLSRNPRGFYLFVEGGRIDHGHHEGVAYQALTEAVMFDDAIERAGQLTSEEDTLTLVTADHSHVFSFGGYTLRGSSIFGLAPSKAQDSKAYTSILYGNGPGYVFNSGVRPDVNESESGSPDYQQQAAVPLSSETHGGEDVAVFARGPQAHLVHGVQEQSFVAHVMAFAACLEPYTACDLAPPACTTDAAHPVAASLPLLAGTLLLLGASAAP
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Lipid-anchor, GPI-anchor.
Function
- Catalytic Activity:
- A phosphate monoester + H(2)O = an alcohol + phosphate.
- Cofactor:
- COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Active Site:
- ACT_SITE 111 111 Phosphoserine intermediate.
- Gene Ontology Go:
- anchored component of membrane
integral component of membrane
plasma membrane
alkaline phosphatase activity
magnesium ion binding
protease binding
zinc ion binding
dephosphorylation - Gene Ontology Biological Process:
- dephosphorylation
- Gene Ontology Molecular Function:
- alkaline phosphatase activity
magnesium ion binding
protease binding
zinc ion binding - Gene Ontology Cellular Component:
- anchored component of membrane
integral component of membrane
plasma membrane - Keywords:
- Cell membrane
Complete proteome
Direct protein sequencing
Disulfide bond
GPI-anchor
Glycoprotein
Hydrolase
Lipoprotein
Magnesium
Membrane
Metal-binding
Polymorphism
Reference proteome
Signal
Transmembrane
Zinc - Interacts With:
- P60410; P60411; Q7Z3S9