Names & Taxonomy
- Uniprot ID:
- P09917
- Entry Name:
- LOX5_HUMAN
- Status:
- reviewed
- Protein Names:
- Arachidonate 5-lipoxygenase (5-LO) (5-lipoxygenase) (EC 1.13.11.34)
- Gene Names:
- ALOX5 LOG5
- Gene Names Primary:
- ALOX5
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 674
- Sequence:
- MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm. Nucleus matrix. Nucleus membrane; Peripheral membrane protein. Note=Shuttles between cytoplasm and nucleus. Found exclusively in the nucleus, when phosphorylated on Ser-272. Calcium binding promotes translocation from the cytosol and the nuclear matrix to the nuclear envelope and membrane association.
Function
- Function:
- Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes.
- Pathway:
- Lipid metabolism; leukotriene A4 biosynthesis.
- Catalytic Activity:
- Arachidonate + O(2) = leukotriene A(4) + H(2)O.
- Cofactor:
- COFACTOR: Name=Fe cation; Xref=ChEBI:CHEBI:24875;
- Cross Reference Drug Bank:
- DB00233 DB01014 DB00586 DB00711 DB00179 DB00939 DB00244 DB01017 DB00471 DB00795 DB00163 DB00744
- Gene Ontology Go:
- cytosol
dendrite
extracellular space
nuclear envelope
nuclear envelope lumen
nuclear matrix
nuclear membrane
sarcolemma
arachidonate 5-lipoxygenase activity
iron ion binding
acute inflammatory response
arachidonic acid metabolic process
leukotriene biosynthetic process
leukotriene metabolic process
leukotriene production involved in inflammatory response
lipoxin metabolic process
lipoxygenase pathway
positive regulation of vasoconstriction
response to hyperoxia
response to nutrient
sensory perception of pain
small molecule metabolic process - Gene Ontology Biological Process:
- acute inflammatory response
arachidonic acid metabolic process
leukotriene biosynthetic process
leukotriene metabolic process
leukotriene production involved in inflammatory response
lipoxin metabolic process
lipoxygenase pathway
positive regulation of vasoconstriction
response to hyperoxia
response to nutrient
sensory perception of pain
small molecule metabolic process - Gene Ontology Molecular Function:
- arachidonate 5-lipoxygenase activity
iron ion binding - Gene Ontology Cellular Component:
- cytosol
dendrite
extracellular space
nuclear envelope
nuclear envelope lumen
nuclear matrix
nuclear membrane
sarcolemma - Keywords:
- 3D-structure
Alternative splicing
Calcium
Complete proteome
Cytoplasm
Dioxygenase
Direct protein sequencing
Iron
Leukotriene biosynthesis
Membrane
Metal-binding
Nucleus
Oxidoreductase
Phosphoprotein
Polymorphism
Reference proteome - Interacts With:
- Q8IYX8-2; Q96MT8; Q14019; P09769; P08631; Q6UWX4; Q9Y6D9; P50221; Q86Y26; P17612; Q04864; Q8N0S2; P07947