Names & Taxonomy

Uniprot ID:
P09693
Entry Name:
CD3G_HUMAN
Status:
reviewed
Protein Names:
T-cell surface glycoprotein CD3 gamma chain (T-cell receptor T3 gamma chain) (CD antigen CD3g)
Gene Names:
CD3G T3G
Gene Names Primary:
CD3G
Organism:
Homo sapiens (Human)

Structure

Length:
182
Sequence:
MEQGKGLAVLILAIILLQGTLAQSIKGNHLVKVYDYQEDGSVLLTCDAEAKNITWFKDGKMIGFLTEDKKKWNLGSNAKDPRGMYQCKGSQNKSKPLQVYYRMCQNCIELNAATISGFLFAEIVSIFVLAVGVYFIAGQDGVRQSRASDKQTLLPNDQLYQPLKDREDDQYSHLQGNQLRRN
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Function

Function:
The CD3 complex mediates signal transduction.
Cross Reference Drug Bank:
DB00075
Gene Ontology Go:
alpha-beta T cell receptor complex
integral component of plasma membrane
plasma membrane
T cell receptor complex
protein heterodimerization activity
receptor signaling complex scaffold activity
T cell receptor binding
transmembrane signaling receptor activity
cell surface receptor signaling pathway
establishment or maintenance of cell polarity
Fc-gamma receptor signaling pathway involved in phagocytosis
innate immune response
protein complex assembly
protein transport
regulation of immune response
regulation of lymphocyte apoptotic process
T cell activation
T cell costimulation
T cell receptor signaling pathway
Gene Ontology Biological Process:
cell surface receptor signaling pathway
establishment or maintenance of cell polarity
Fc-gamma receptor signaling pathway involved in phagocytosis
innate immune response
protein complex assembly
protein transport
regulation of immune response
regulation of lymphocyte apoptotic process
T cell activation
T cell costimulation
T cell receptor signaling pathway
Gene Ontology Molecular Function:
protein heterodimerization activity
receptor signaling complex scaffold activity
T cell receptor binding
transmembrane signaling receptor activity
Gene Ontology Cellular Component:
alpha-beta T cell receptor complex
integral component of plasma membrane
plasma membrane
T cell receptor complex
Keywords:
3D-structure
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
Immunoglobulin domain
Membrane
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Signal
Transmembrane
Transmembrane helix

Publication

PubMed ID:
2944745 2826124 15489334 2540970 3112151 1535555 1635567 17277165 19690332 15136729