Names & Taxonomy

Uniprot ID:
P08842
Entry Name:
STS_HUMAN
Status:
reviewed
Protein Names:
Steryl-sulfatase (EC 3.1.6.2) (Arylsulfatase C) (ASC) (Steroid sulfatase) (Steryl-sulfate sulfohydrolase)
Gene Names:
STS ARSC1
Gene Names Primary:
STS
Organism:
Homo sapiens (Human)

Structure

Length:
583
Sequence:
MPLRKMKIPFLLLFFLWEAESHAASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRAAFMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKWHLGMSCHSKTDFCHHPLHHGFNYFYGISLTNLRDCKPGEGSVFTTGFKRLVFLPLQIVGVTLLTLAALNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPLNCFMMRNYEIIQQPMSYDNLTQRLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSKDFAGKSQHGVYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRDLMPLLEGKSQRSDHEFLFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVGSNGCFATHVCFCFGSYVTHHDPPLLFDISKDPRERNPLTPASEPRFYEILKVMQEAADRHTQTLPEVPDQFSWNNFLWKPWLQLCCPSTGLSCQCDREKQDKRLSR
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Endoplasmic reticulum membrane; Multi-pass membrane protein.

Function

Function:
Conversion of sulfated steroid precursors to estrogens during pregnancy.
Catalytic Activity:
3-beta-hydroxyandrost-5-en-17-one 3-sulfate + H(2)O = 3-beta-hydroxyandrost-5-en-17-one + sulfate.
Cofactor:
COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
Active Site:
ACT_SITE 136 136
Cross Reference Drug Bank:
DB06713
Gene Ontology Go:
endoplasmic reticulum
endoplasmic reticulum lumen
endoplasmic reticulum membrane
endosome
Golgi apparatus
integral component of membrane
intracellular membrane-bounded organelle
lysosome
membrane
nuclear envelope
plasma membrane
metal ion binding
steryl-sulfatase activity
sulfuric ester hydrolase activity
cellular protein metabolic process
epidermis development
female pregnancy
glycosphingolipid metabolic process
learning or memory
positive regulation of cell proliferation
post-translational protein modification
response to estrogen
response to peptide hormone
response to pH
skin development
small molecule metabolic process
sphingolipid metabolic process
steroid catabolic process
Gene Ontology Biological Process:
cellular protein metabolic process
epidermis development
female pregnancy
glycosphingolipid metabolic process
learning or memory
positive regulation of cell proliferation
post-translational protein modification
response to estrogen
response to peptide hormone
response to pH
skin development
small molecule metabolic process
sphingolipid metabolic process
steroid catabolic process
Gene Ontology Molecular Function:
metal ion binding
steryl-sulfatase activity
sulfuric ester hydrolase activity
Gene Ontology Cellular Component:
endoplasmic reticulum
endoplasmic reticulum lumen
endoplasmic reticulum membrane
endosome
Golgi apparatus
integral component of membrane
intracellular membrane-bounded organelle
lysosome
membrane
nuclear envelope
plasma membrane
Keywords:
3D-structure
Calcium
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
Endoplasmic reticulum
Glycoprotein
Hydrolase
Ichthyosis
Lipid metabolism
Membrane
Metal-binding
Pregnancy
Reference proteome
Signal
Steroid metabolism
Transmembrane
Transmembrane helix

Publication

PubMed ID:
2668275 3032454 14702039 15489334 3203382 2765556 12657638 1539590 9252398 10679952 10844566