Names & Taxonomy
- Uniprot ID:
- P08758
- Entry Name:
- ANXA5_HUMAN
- Status:
- reviewed
- Protein Names:
- Annexin A5 (Anchorin CII) (Annexin V) (Annexin-5) (Calphobindin I) (CBP-I) (Endonexin II) (Lipocortin V) (Placental anticoagulant protein 4) (PP4) (Placental anticoagulant protein I) (PAP-I) (Thromboplastin inhibitor) (Vascular anticoagulant-alpha) (VAC-alpha)
- Gene Names:
- ANXA5 ANX5 ENX2 PP4
- Gene Names Primary:
- ANXA5
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 320
- Sequence:
- MAQVLRGTVTDFPGFDERADAETLRKAMKGLGTDEESILTLLTSRSNAQRQEISAAFKTLFGRDLLDDLKSELTGKFEKLIVALMKPSRLYDAYELKHALKGAGTNEKVLTEIIASRTPEELRAIKQVYEEEYGSSLEDDVVGDTSGYYQRMLVVLLQANRDPDAGIDEAQVEQDAQALFQAGELKWGTDEEKFITIFGTRSVSHLRKVFDKYMTISGFQIEETIDRETSGNLEQLLLAVVKSIRSIPAYLAETLYYAMKGAGTDDHTLIRVMVSRSEIDLFNIRKEFRKNFATSLYSMIKGDTSGDYKKALLLLCGEDD
- Proteomes:
- UP000005640
Function
- Function:
- This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.
- Gene Ontology Go:
- axon terminus
cytoplasm
cytosol
dendrite
endoplasmic reticulum
endothelial microparticle
external side of plasma membrane
extracellular exosome
focal adhesion
intercalated disc
intracellular
membrane
nucleus
perikaryon
sarcolemma
synaptic vesicle
Z disc
calcium ion binding
calcium-dependent phospholipid binding
calcium-transporting ATPase activity
peptide hormone binding
phospholipase inhibitor activity
phospholipid binding
blood coagulation
cellular response to gonadotropin-releasing hormone
cellular response to lead ion
mitophagy in response to mitochondrial depolarization
negative regulation of apoptotic process
negative regulation of blood coagulation
negative regulation of catalytic activity
negative regulation of prolactin secretion
positive regulation of apoptotic process
positive regulation of defense response to virus by host
protein homooligomerization
regulation of sperm motility
response to calcium ion
response to thyroid hormone
signal transduction
xenophagy - Gene Ontology Biological Process:
- blood coagulation
cellular response to gonadotropin-releasing hormone
cellular response to lead ion
mitophagy in response to mitochondrial depolarization
negative regulation of apoptotic process
negative regulation of blood coagulation
negative regulation of catalytic activity
negative regulation of prolactin secretion
positive regulation of apoptotic process
positive regulation of defense response to virus by host
protein homooligomerization
regulation of sperm motility
response to calcium ion
response to thyroid hormone
signal transduction
xenophagy - Gene Ontology Molecular Function:
- calcium-dependent phospholipid binding
calcium ion binding
calcium-transporting ATPase activity
peptide hormone binding
phospholipase inhibitor activity
phospholipid binding - Gene Ontology Cellular Component:
- axon terminus
cytoplasm
cytosol
dendrite
endoplasmic reticulum
endothelial microparticle
external side of plasma membrane
extracellular exosome
focal adhesion
intercalated disc
intracellular
membrane
nucleus
perikaryon
sarcolemma
synaptic vesicle
Z disc - Keywords:
- 3D-structure
Acetylation
Annexin
Blood coagulation
Calcium
Calcium/phospholipid-binding
Complete proteome
Direct protein sequencing
Hemostasis
Isopeptide bond
Phosphoprotein
Reference proteome
Repeat
S-nitrosylation
Ubl conjugation - Interacts With:
- Q9BSI4