Names & Taxonomy
- Uniprot ID:
- P08697
- Entry Name:
- A2AP_HUMAN
- Status:
- reviewed
- Protein Names:
- Alpha-2-antiplasmin (Alpha-2-AP) (Alpha-2-plasmin inhibitor) (Alpha-2-PI) (Serpin F2)
- Gene Names:
- SERPINF2 AAP PLI
- Gene Names Primary:
- SERPINF2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 491
- Sequence:
- MALLWGLLVLSWSCLQGPCSVFSPVSAMEPLGRQLTSGPNQEQVSPLTLLKLGNQEPGGQTALKSPPGVCSRDPTPEQTHRLARAMMAFTADLFSLVAQTSTCPNLILSPLSVALALSHLALGAQNHTLQRLQQVLHAGSGPCLPHLLSRLCQDLGPGAFRLAARMYLQKGFPIKEDFLEQSEQLFGAKPVSLTGKQEDDLANINQWVKEATEGKIQEFLSGLPEDTVLLLLNAIHFQGFWRNKFDPSLTQRDSFHLDEQFTVPVEMMQARTYPLRWFLLEQPEIQVAHFPFKNNMSFVVLVPTHFEWNVSQVLANLSWDTLHPPLVWERPTKVRLPKLYLKHQMDLVATLSQLGLQELFQAPDLRGISEQSLVVSGVQHQSTLELSEVGVEAAAATSIAMSRMSLSSFSVNRPFLFFIFEDTTGLPLFVGSVRNPNPSAPRELKEQQDSPGNKDFLQSLKGFPRGDKLFGPDLKLVPPMEEDYPQFGSPK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted.
Function
- Function:
- Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin.
- Cross Reference Drug Bank:
- DB08888
- Gene Ontology Go:
- blood microparticle
cell surface
extracellular exosome
extracellular region
extracellular space
fibrinogen complex
platelet alpha granule lumen
endopeptidase inhibitor activity
protease binding
protein homodimerization activity
serine-type endopeptidase inhibitor activity
acute-phase response
blood coagulation
blood vessel morphogenesis
collagen fibril organization
fibrinolysis
negative regulation of endopeptidase activity
negative regulation of fibrinolysis
negative regulation of plasminogen activation
platelet activation
platelet degranulation
positive regulation of cell differentiation
positive regulation of cell-cell adhesion mediated by cadherin
positive regulation of collagen biosynthetic process
positive regulation of ERK1 and ERK2 cascade
positive regulation of JNK cascade
positive regulation of smooth muscle cell proliferation
positive regulation of stress fiber assembly
positive regulation of transcription from RNA polymerase II promoter
positive regulation of transforming growth factor beta production
regulation of blood vessel size by renin-angiotensin
response to organic substance - Gene Ontology Biological Process:
- acute-phase response
blood coagulation
blood vessel morphogenesis
collagen fibril organization
fibrinolysis
negative regulation of endopeptidase activity
negative regulation of fibrinolysis
negative regulation of plasminogen activation
platelet activation
platelet degranulation
positive regulation of cell-cell adhesion mediated by cadherin
positive regulation of cell differentiation
positive regulation of collagen biosynthetic process
positive regulation of ERK1 and ERK2 cascade
positive regulation of JNK cascade
positive regulation of smooth muscle cell proliferation
positive regulation of stress fiber assembly
positive regulation of transcription from RNA polymerase II promoter
positive regulation of transforming growth factor beta production
regulation of blood vessel size by renin-angiotensin
response to organic substance - Gene Ontology Molecular Function:
- endopeptidase inhibitor activity
protease binding
protein homodimerization activity
serine-type endopeptidase inhibitor activity - Gene Ontology Cellular Component:
- blood microparticle
cell surface
extracellular exosome
extracellular region
extracellular space
fibrinogen complex
platelet alpha granule lumen - Keywords:
- Acute phase
Alternative splicing
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
Glycoprotein
Isopeptide bond
Polymorphism
Protease inhibitor
Reference proteome
Secreted
Serine protease inhibitor
Signal
Sulfation