Names & Taxonomy

Uniprot ID:
P08319
Entry Name:
ADH4_HUMAN
Status:
reviewed
Protein Names:
Alcohol dehydrogenase 4 (EC 1.1.1.1) (Alcohol dehydrogenase class II pi chain)
Gene Names:
ADH4
Gene Names Primary:
ADH4
Organism:
Homo sapiens (Human)

Structure

Length:
380
Sequence:
MGTKGKVIKCKAAIAWEAGKPLCIEEVEVAPPKAHEVRIQIIATSLCHTDATVIDSKFEGLAFPVIVGHEAAGIVESIGPGVTNVKPGDKVIPLYAPLCRKCKFCLSPLTNLCGKISNLKSPASDQQLMEDKTSRFTCKGKPVYHFFGTSTFSQYTVVSDINLAKIDDDANLERVCLLGCGFSTGYGAAINNAKVTPGSTCAVFGLGGVGLSAVMGCKAAGASRIIGIDINSEKFVKAKALGATDCLNPRDLHKPIQEVIIELTKGGVDFALDCAGGSETMKAALDCTTAGWGSCTFIGVAAGSKGLTIFPEELIIGRTINGTFFGGWKSVDSIPKLVTDYKNKKFNLDALVTHTLPFDKISEAFDLMNQGKSVRTILIF
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm.

Function

Catalytic Activity:
An alcohol + NAD(+) = an aldehyde or ketone + NADH.
Cofactor:
COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; ; Note=Binds 2 Zn(2+) ions per subunit.;
Cross Reference Drug Bank:
DB00898
Gene Ontology Go:
cytosol
alcohol dehydrogenase (NAD) activity
alcohol dehydrogenase activity, zinc-dependent
alditol:NADP+ 1-oxidoreductase activity
all-trans retinal binding
benzaldehyde dehydrogenase activity
ethanol binding
NAD binding
NADPH:quinone reductase activity
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
retinol binding
retinol dehydrogenase activity
zinc ion binding
alcohol catabolic process
alcohol metabolic process
cellular aldehyde metabolic process
ethanol oxidation
quinone metabolic process
retinoid metabolic process
retinol metabolic process
small molecule metabolic process
xenobiotic metabolic process
Gene Ontology Biological Process:
alcohol catabolic process
alcohol metabolic process
cellular aldehyde metabolic process
ethanol oxidation
quinone metabolic process
retinoid metabolic process
retinol metabolic process
small molecule metabolic process
xenobiotic metabolic process
Gene Ontology Molecular Function:
alcohol dehydrogenase (NAD) activity
alcohol dehydrogenase activity, zinc-dependent
alditol:NADP+ 1-oxidoreductase activity
all-trans retinal binding
benzaldehyde dehydrogenase activity
ethanol binding
NAD binding
NADPH:quinone reductase activity
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
retinol binding
retinol dehydrogenase activity
zinc ion binding
Gene Ontology Cellular Component:
cytosol
Keywords:
3D-structure
Alternative splicing
Complete proteome
Cytoplasm
Direct protein sequencing
Metal-binding
NAD
Oxidoreductase
Phosphoprotein
Polymorphism
Reference proteome
Zinc

Publication

PubMed ID:
3036213 1889753 14702039 15815621 15489334 24275569