Names & Taxonomy
- Uniprot ID:
- P08237
- Entry Name:
- PFKAM_HUMAN
- Status:
- reviewed
- Protein Names:
- ATP-dependent 6-phosphofructokinase, muscle type (ATP-PFK) (PFK-M) (EC 2.7.1.11) (6-phosphofructokinase type A) (Phosphofructo-1-kinase isozyme A) (PFK-A) (Phosphohexokinase)
- Gene Names:
- PFKM PFKX
- Gene Names Primary:
- PFKM
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 780
- Sequence:
- MTHEEHHAAKTLGIGKAIAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGGDHIKEATWESVSMMLQLGGTVIGSARCKDFREREGRLRAAYNLVKRGITNLCVIGGDGSLTGADTFRSEWSDLLSDLQKAGKITDEEATKSSYLNIVGLVGSIDNDFCGTDMTIGTDSALHRIMEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDDDWEEHLCRRLSETRTRGSRLNIIIVAEGAIDKNGKPITSEDIKNLVVKRLGYDTRVTVLGHVQRGGTPSAFDRILGSRMGVEAVMALLEGTPDTPACVVSLSGNQAVRLPLMECVQVTKDVTKAMDEKKFDEALKLRGRSFMNNWEVYKLLAHVRPPVSKSGSHTVAVMNVGAPAAGMNAAVRSTVRIGLIQGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGSKLGTKRTLPKKSFEQISANITKFNIQGLVIIGGFEAYTGGLELMEGRKQFDELCIPFVVIPATVSNNVPGSDFSVGADTALNTICTTCDRIKQSAAGTKRRVFIIETMGGYCGYLATMAGLAAGADAAYIFEEPFTIRDLQANVEHLVQKMKTTVKRGLVLRNEKCNENYTTDFIFNLYSEEGKGIFDSRKNVLGHMQQGGSPTPFDRNFATKMGAKAMNWMSGKIKESYRNGRIFANTPDSGCVLGMRKRALVFQPVAELKDQTDFEHRIPKEQWWLKLRPILKILAKYEIDLDTSDHAHLEHITRKRSGEAAV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
- Pathway:
- Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.
- Catalytic Activity:
- ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate.
- Cofactor:
- COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Enzyme Regulation:
- ENZYME REGULATION: Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.
- Active Site:
- ACT_SITE 166 166 Proton acceptor.
- Gene Ontology Go:
- 6-phosphofructokinase complex
apical plasma membrane
cytosol
extracellular exosome
sperm principal piece
6-phosphofructokinase activity
ATP binding
fructose binding
identical protein binding
kinase binding
metal ion binding
protein C-terminus binding
canonical glycolysis
carbohydrate metabolic process
fructose 6-phosphate metabolic process
glucose homeostasis
glucose metabolic process
glycogen catabolic process
glycolysis from storage polysaccharide through glucose-1-phosphate
glycolytic process
muscle cell cellular homeostasis
positive regulation of insulin secretion
protein oligomerization
small molecule metabolic process - Gene Ontology Biological Process:
- canonical glycolysis
carbohydrate metabolic process
fructose 6-phosphate metabolic process
glucose homeostasis
glucose metabolic process
glycogen catabolic process
glycolysis from storage polysaccharide through glucose-1-phosphate
glycolytic process
muscle cell cellular homeostasis
positive regulation of insulin secretion
protein oligomerization
small molecule metabolic process - Gene Ontology Molecular Function:
- 6-phosphofructokinase activity
ATP binding
fructose binding
identical protein binding
kinase binding
metal ion binding
protein C-terminus binding - Gene Ontology Cellular Component:
- 6-phosphofructokinase complex
apical plasma membrane
cytosol
extracellular exosome
sperm principal piece - Keywords:
- 3D-structure
ATP-binding
Acetylation
Allosteric enzyme
Alternative splicing
Complete proteome
Cytoplasm
Disease mutation
Glycogen storage disease
Glycolysis
Glycoprotein
Kinase
Magnesium
Metal-binding
Nucleotide-binding
Phosphoprotein
Reference proteome
Transferase - Interacts With:
- Itself; P17858; Q8IUQ4