Names & Taxonomy
- Uniprot ID:
- P08235
- Entry Name:
- MCR_HUMAN
- Status:
- reviewed
- Protein Names:
- Mineralocorticoid receptor (MR) (Nuclear receptor subfamily 3 group C member 2)
- Gene Names:
- NR3C2 MCR MLR
- Gene Names Primary:
- NR3C2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 984
- Sequence:
- METKGYHSLPEGLDMERRWGQVSQAVERSSLGPTERTDENNYMEIVNVSCVSGAIPNNSTQGSSKEKQELLPCLQQDNNRPGILTSDIKTELESKELSATVAESMGLYMDSVRDADYSYEQQNQQGSMSPAKIYQNVEQLVKFYKGNGHRPSTLSCVNTPLRSFMSDSGSSVNGGVMRAIVKSPIMCHEKSPSVCSPLNMTSSVCSPAGINSVSSTTASFGSFPVHSPITQGTPLTCSPNAENRGSRSHSPAHASNVGSPLSSPLSSMKSSISSPPSHCSVKSPVSSPNNVTLRSSVSSPANINNSRCSVSSPSNTNNRSTLSSPAASTVGSICSPVNNAFSYTASGTSAGSSTLRDVVPSPDTQEKGAQEVPFPKTEEVESAISNGVTGQLNIVQYIKPEPDGAFSSSCLGGNSKINSDSSFSVPIKQESTKHSCSGTSFKGNPTVNPFPFMDGSYFSFMDDKDYYSLSGILGPPVPGFDGNCEGSGFPVGIKQEPDDGSYYPEASIPSSAIVGVNSGGQSFHYRIGAQGTISLSRSARDQSFQHLSSFPPVNTLVESWKSHGDLSSRRSDGYPVLEYIPENVSSSTLRSVSTGSSRPSKICLVCGDEASGCHYGVVTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRLQKCLQAGMNLGARKSKKLGKLKGIHEEQPQQQQPPPPPPPPQSPEEGTTYIAPAKEPSVNTALVPQLSTISRALTPSPVMVLENIEPEIVYAGYDSSKPDTAENLLSTLNRLAGKQMIQVVKWAKVLPGFKNLPLEDQITLIQYSWMCLSSFALSWRSYKHTNSQFLYFAPDLVFNEEKMHQSAMYELCQGMHQISLQFVRLQLTFEEYTIMKVLLLLSTIPKDGLKSQAAFEEMRTNYIKELRKMVTKCPNNSGQSWQRFYQLTKLLDSMHDLVSDLLEFCFYTFRESHALKVEFPAMLVEIISDQLPKVESGNAKPLYFHRK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm. Nucleus. Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Cytoplasmic and nuclear in the absence of ligand; nuclear after ligand-binding. When bound to HSD11B2, it is found associated with the endoplasmic reticulum membrane.
Function
- Function:
- Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels.
- Cross Reference Drug Bank:
- DB01395 DB00700 DB01023 DB00687 DB00588 DB00393 DB00396 DB00421
- Gene Ontology Go:
- endoplasmic reticulum membrane
nucleoplasm
receptor complex
sequence-specific DNA binding
steroid binding
steroid hormone receptor activity
transcription factor activity, sequence-specific DNA binding
zinc ion binding
gene expression
signal transduction
transcription initiation from RNA polymerase II promoter - Gene Ontology Biological Process:
- gene expression
signal transduction
transcription initiation from RNA polymerase II promoter - Gene Ontology Molecular Function:
- sequence-specific DNA binding
steroid binding
steroid hormone receptor activity
transcription factor activity, sequence-specific DNA binding
zinc ion binding - Gene Ontology Cellular Component:
- endoplasmic reticulum membrane
nucleoplasm
receptor complex - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Cytoplasm
DNA-binding
Disease mutation
Endoplasmic reticulum
Lipid-binding
Membrane
Metal-binding
Nucleus
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Steroid-binding
Transcription
Transcription regulation
Zinc
Zinc-finger