Names & Taxonomy

Uniprot ID:
P08174
Entry Name:
DAF_HUMAN
Status:
reviewed
Protein Names:
Complement decay-accelerating factor (CD antigen CD55)
Gene Names:
CD55 CR DAF
Gene Names Primary:
CD55
Organism:
Homo sapiens (Human)

Structure

Length:
381
Sequence:
MTVARPSVPAALPLLGELPRLLLLVLLCLPAVWGDCGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCNRSCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECREIYCPAPPQIDNGIIQGERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPECRGKSLTSKVPPTVQKPTTVNVPTTEVSPTSQKTTTKTTTPNAQATRSTPVSRTTKHFHETTPNKGSGTTSGTTRLLSGHTCFTLTGLLGTLVTMGLLT
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Isoform 1: Cell membrane; Single-pass type I membrane protein.; Isoform 2: Cell membrane; Lipid-anchor, GPI-anchor.; Isoform 3: Secreted

Function

Function:
This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade.
Cross Reference Drug Bank:
DB00446
Gene Ontology Go:
anchored component of membrane
cell surface
endoplasmic reticulum-Golgi intermediate compartment membrane
extracellular exosome
extracellular region
Golgi membrane
integral component of plasma membrane
membrane raft
plasma membrane
transport vesicle
lipid binding
virus receptor activity
CD4-positive, alpha-beta T cell cytokine production
cellular protein metabolic process
complement activation, classical pathway
ER to Golgi vesicle-mediated transport
innate immune response
membrane organization
negative regulation of complement activation
positive regulation of CD4-positive, alpha-beta T cell activation
positive regulation of CD4-positive, alpha-beta T cell proliferation
positive regulation of cytosolic calcium ion concentration
post-translational protein modification
protein N-linked glycosylation via asparagine
regulation of complement activation
regulation of lipopolysaccharide-mediated signaling pathway
respiratory burst
viral entry into host cell
Gene Ontology Biological Process:
CD4-positive, alpha-beta T cell cytokine production
cellular protein metabolic process
complement activation, classical pathway
ER to Golgi vesicle-mediated transport
innate immune response
membrane organization
negative regulation of complement activation
positive regulation of CD4-positive, alpha-beta T cell activation
positive regulation of CD4-positive, alpha-beta T cell proliferation
positive regulation of cytosolic calcium ion concentration
post-translational protein modification
protein N-linked glycosylation via asparagine
regulation of complement activation
regulation of lipopolysaccharide-mediated signaling pathway
respiratory burst
viral entry into host cell
Gene Ontology Molecular Function:
lipid binding
virus receptor activity
Gene Ontology Cellular Component:
anchored component of membrane
cell surface
endoplasmic reticulum-Golgi intermediate compartment membrane
extracellular exosome
extracellular region
Golgi membrane
integral component of plasma membrane
membrane raft
plasma membrane
transport vesicle
Keywords:
3D-structure
Alternative splicing
Blood group antigen
Cell membrane
Complement pathway
Complete proteome
Direct protein sequencing
Disulfide bond
GPI-anchor
Glycoprotein
Host cell receptor for virus entry
Host-virus interaction
Immunity
Innate immunity
Lipoprotein
Membrane
Polymorphism
Receptor
Reference proteome
Repeat
Secreted
Signal
Sushi

Publication

PubMed ID:
2433596 16503113 16710414 15489334 1711208 2436222 2428813 1712233 1824699 1377029 7525274 7517044 7538177 8764022 9151867 12409401 14517339 16602701 17804498 19159218 21269460 26207632 7519480 12675719 1720702 12499389 14734808 12672958