Names & Taxonomy
- Uniprot ID:
- P07998
- Entry Name:
- RNAS1_HUMAN
- Status:
- reviewed
- Protein Names:
- Ribonuclease pancreatic (EC 3.1.27.5) (HP-RNase) (RIB-1) (RNase UpI-1) (Ribonuclease 1) (RNase 1) (Ribonuclease A) (RNase A)
- Gene Names:
- RNASE1 RIB1 RNS1
- Gene Names Primary:
- RNASE1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 156
- Sequence:
- MALEKSLVRLLLLVLILLVLGWVQPSLGKESRAKKFQRQHMDSDSSPSSSSTYCNQMMRRRNMTQGRCKPVNTFVHEPLVDVQNVCFQEKVTCKNGQGNCYKSNSSMHITDCRLTNGSRYPNCAYRTSPKERHIIVACEGSPYVPVHFDASVEDST
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted.
Function
- Function:
- Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single-stranded and double-stranded RNA.
- Catalytic Activity:
- Endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates.
- Active Site:
- ACT_SITE 40 40 Proton acceptor.; ACT_SITE 147 147 Proton donor.
- Cross Reference Drug Bank:
- DB00536 DB02325 DB00128
- Gene Ontology Go:
- extracellular exosome
nucleic acid binding
ribonuclease A activity
RNA phosphodiester bond hydrolysis, endonucleolytic - Gene Ontology Biological Process:
- RNA phosphodiester bond hydrolysis, endonucleolytic
- Gene Ontology Molecular Function:
- nucleic acid binding
ribonuclease A activity - Gene Ontology Cellular Component:
- extracellular exosome
- Keywords:
- 3D-structure
Complete proteome
Direct protein sequencing
Disulfide bond
Endonuclease
Glycoprotein
Hydrolase
Nuclease
Reference proteome
Secreted
Signal - Interacts With:
- P13489