Names & Taxonomy

Uniprot ID:
P07766
Entry Name:
CD3E_HUMAN
Status:
reviewed
Protein Names:
T-cell surface glycoprotein CD3 epsilon chain (T-cell surface antigen T3/Leu-4 epsilon chain) (CD antigen CD3e)
Gene Names:
CD3E T3E
Gene Names Primary:
CD3E
Organism:
Homo sapiens (Human)

Structure

Length:
207
Sequence:
MQSGTHWRVLGLCLLSVGVWGQDGNEEMGGITQTPYKVSISGTTVILTCPQYPGSEILWQHNDKNIGGDEDDKNIGSDEDHLSLKEFSELEQSGYYVCYPRGSKPEDANFYLYLRARVCENCMEMDVMSVATIVIVDICITGGLLLLVYYWSKNRKAKAKPVTRGAGAGGRQRGQNKERPPPVPNPDYEPIRKGQRDLYSGLNQRRI
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane

Function

Function:
The CD3 complex mediates signal transduction, resulting in T-cell activation and proliferation. Required for normal immune responses (PubMed:15546002, PubMed:8490660).
Cross Reference Drug Bank:
DB00075
Gene Ontology Go:
alpha-beta T cell receptor complex
cell-cell junction
external side of plasma membrane
immunological synapse
integral component of plasma membrane
intracellular
plasma membrane
T cell receptor complex
protein heterodimerization activity
protein kinase binding
receptor signaling complex scaffold activity
receptor signaling protein activity
SH3 domain binding
T cell receptor binding
transmembrane signaling receptor activity
apoptotic signaling pathway
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
negative regulation of gene expression
negative regulation of smoothened signaling pathway
negative thymic T cell selection
positive regulation of alpha-beta T cell proliferation
positive regulation of calcium-mediated signaling
positive regulation of gene expression
positive regulation of interferon-gamma production
positive regulation of interleukin-2 biosynthetic process
positive regulation of interleukin-4 production
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of T cell anergy
positive regulation of T cell proliferation
protein complex assembly
regulation of apoptotic process
regulation of immune response
response to nutrient
signal complex assembly
T cell activation
T cell costimulation
T cell receptor signaling pathway
transmembrane receptor protein tyrosine kinase signaling pathway
Gene Ontology Biological Process:
apoptotic signaling pathway
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
negative regulation of gene expression
negative regulation of smoothened signaling pathway
negative thymic T cell selection
positive regulation of alpha-beta T cell proliferation
positive regulation of calcium-mediated signaling
positive regulation of gene expression
positive regulation of interferon-gamma production
positive regulation of interleukin-2 biosynthetic process
positive regulation of interleukin-4 production
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of T cell anergy
positive regulation of T cell proliferation
protein complex assembly
regulation of apoptotic process
regulation of immune response
response to nutrient
signal complex assembly
T cell activation
T cell costimulation
T cell receptor signaling pathway
transmembrane receptor protein tyrosine kinase signaling pathway
Gene Ontology Molecular Function:
protein heterodimerization activity
protein kinase binding
receptor signaling complex scaffold activity
receptor signaling protein activity
SH3 domain binding
T cell receptor binding
transmembrane signaling receptor activity
Gene Ontology Cellular Component:
alpha-beta T cell receptor complex
cell-cell junction
external side of plasma membrane
immunological synapse
integral component of plasma membrane
intracellular
plasma membrane
T cell receptor complex
Keywords:
3D-structure
Cell membrane
Complete proteome
Disulfide bond
Immunity
Immunoglobulin domain
Membrane
Phosphoprotein
Receptor
Reference proteome
Signal
Transmembrane
Transmembrane helix
Interacts With:
Q8TE68; P16333; P43405; P43403

Publication

PubMed ID:
3012357 3267235 14702039 15489334 8490660 12522270 15144186 15546002 15294938 15592455 19690332 9698567 15136729 15534202